Publications by authors named "Raquel Felipe"
Article Synopsis
- The glycine transporter GlyT2 regulates inhibitory neurotransmission by controlling glycine levels in the spinal cord, impacting pain signaling pathways.
- Blocking GlyT2 with selective inhibitors like ALX1393 and ORG25543 increases extracellular glycine, providing analgesic effects but with limitations for clinical use.
- Research utilizing molecular simulations and docking studies reveals how these inhibitors interact differently with GlyT2, which could aid in the development of more effective pain relief drugs.
The neuronal glycine transporter GlyT2 modulates inhibitory glycinergic neurotransmission and plays a key role in regulating nociceptive signal progression. The cholinergic system acting through muscarinic acetylcholine receptors (mAChRs) also mediates important regulations of nociceptive transmission being the M2 subtype the most abundantly expressed in the spinal cord. Here we studied the effect of M2 mAChRs stimulation on GlyT2 function co-expressed in a heterologous system with negligible levels of muscarinic receptor activity.
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