Publications by authors named "Raquel Cristina Cavalcanti Dantas"
Stingless bees are a diverse group with a relevant role in pollinating native species. Its diet is rich in carbohydrates and proteins, by collecting pollen and nectar supplies the development of its offspring. Fermentation of these products is associated with microorganisms in the colony.
View Article and Find Full Text PDFBackground: The discovery of new molecules with antimicrobial properties has been a promising approach, mainly when related to substances produced by bacteria. The use of substances produced by bees has evidenced the antimicrobial action in different types of organisms. Thus, the use of bacteria isolated from larval food of stingless bees opens the way for the identification of the new molecules.
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- A retrospective study analyzed the factors contributing to bacteremia caused by multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosa, focusing on overexpressed efflux pumps and changes in porin structures.
- Molecular techniques like Pulsed Field Gel Electrophoresis and PCR were utilized to assess strain typing and identify key resistance genes, revealing a strong link between prior carbapenem use and bacteremia development.
- Among non-Metallo-β-Lactamase isolates, there was a notable prevalence of AmpC overproduction and alterations in OprD porin, indicating that intrinsic resistance mechanisms play a significant role in promoting multi-drug resistance.
Pseudomonas aeruginosa is an opportunistic pathogen that causes frequently nosocomial infections, currently becoming more difficult to treat due to the various resistance mechanisms and different virulence factors. The purpose of this study was to determine the risk factors independently associated with the development of bacteremia by carbapenem-resistant P. aeruginosa, the frequency of virulence genes in metallo-β-lactamases producers and to evaluate their ability to produce biofilm.
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- * Our case-control study revealed a high rate of MDR isolates (40.7%), with over half associated with inappropriate antibiotic therapy, resulting in significant complications for patients with bacteremia.
- * Notably, we found mutations related to antibiotic resistance in almost all isolates, and we reported for the first time in Brazil the presence of specific resistance genes in isolates, emphasizing the urgent need for proper antibiotic treatment.