An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers.

Introduction: Individuals carrying pathogenic mutations in the BRCA1 and BRCA2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double-strand break repair, DNA alterations that can be caused by exposure to reactive oxygen species, a main source of which are mitochondria. Mitochondrial genome variations affect electron transport chain efficiency and reactive oxygen species production.

Neonatal lupus erythematosus mimicking extensive capillary malformation.

Neonatal lupus erythematosus is an uncommon transplacentally acquired autoimmune disorder. We report a 7-month-old boy with cutaneous involvement of neonatal lupus erythematosus mimicking an extensive capillary malformation.

Neonatal Lupus Erythematosus Mimicking Extensive Capillary Malformation.

  Neonatal lupus erythematosus is an uncommon transplacentally acquired autoimmune disorder. We report a 7-month-old boy with cutaneous involvement of neonatal lupus erythematosus mimicking an extensive capillary malformation.