Publications by authors named "Raquel Becerra"
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- Neddylation, a type of protein modification similar to ubiquitination, is not as well-understood, especially regarding its non-cullin substrates.
- Researchers developed a method called serial NEDD8-ubiquitin substrate profiling (sNUSP) to identify neddylation sites in proteins, discovering 607 sites influenced by specific inhibitors and enzymes.
- One significant finding was the neddylation of the actin regulator cofilin at lysine 112, which impacts neuronal development by affecting actin dynamics and neurite growth, highlighting its role in neuronal organization.
Immunoglobulin E-mediated allergy and certain autoimmune diseases are characterized by the presence of a T helper type 2 (Th2) immune response and allergen-specific or self-reactive IgE. Soluble CD23 (sCD23) is a B-cell factor that fosters IgE class-switching and synthesis, suggesting that sCD23 may be a therapeutic target for these pathologies. We produced a recombinant protein, CTLA4Fcε, by fusing the ectodomain of the immunoregulatory molecule cytotoxic T-lymphocyte antigen 4 (CTLA-4) with a fragment of the IgE H-chain constant region.
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