Synthesis, Bioevaluation and Molecular Dynamic Simulation Studies of Dexibuprofen-Antioxidant Mutual Prodrugs.

Dexibuprofen-antioxidant conjugates were synthesized with the aim to reduce its gastrointestinal effects. The esters analogs of dexibuprofen - were obtained by reacting its -COOH group with chloroacetyl derivatives -. The in vitro hydrolysis data confirmed that synthesized prodrugs - were stable in stomach while undergo significant hydrolysis in 80% human plasma and thus release free dexibuprofen.