Synthesis, spectral characterization and antiproliferative activity of new organotin (IV) dithiocarbamate compounds on K562 cells.

Four new organotin(IV) dithiocarbamate compounds with general formulae of PhnSn [SCN(CHCHOCHCH)] for compound 1 and 2; and PhSn[SCN(CH)(CHCHCH)] for compound 3 and 4 were successfully synthesized via in situ insertion method. These compounds namely, diphenyltin(IV)- [1] and triphenyltin(IV) N,N-bis(2-ethoxyethyl)dithiocarbamate [2], diphenyltin(IV)- [3] and triphenyltin(IV) N-methyl-N-phenethyldithiocarbamate [4] were each characterized with CHNS elemental analysis, FT-IR and NMR spectroscopies (H, C and Sn). The compounds were then assessed for their cytotoxicity against K562 cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazholium bromide (MTT) assay upon 24 h treatment.

Synthesis and cytotoxic activity of organotin(IV) diallyldithiocarbamate compounds as anticancer agent towards colon adenocarcinoma cells (HT-29).

Context: Diphenyltin(IV) diallyldithiocarbamate compound (Compound ) and triphenyltin(IV) diallyldithiocarbamate compound (Compound ) are two newly synthesised compounds of organotin(IV) with diallyldithiocarbamate ligands.

Objective: To assess the cytotoxic effects of two synthesised compounds against HT-29 human colon adenocarcinoma cells and human CCD-18Co normal colon cells.

Materials And Methods: Two successfully synthesised compounds were characterised using elemental (carbon, hydrogen, nitrogen, and sulphur) analysis, Fourier-Transform Infrared (FTIR), and H, C Sn Nucleus Magnetic Resonance (NMR) spectroscopies.

Crystal structures and Hirshfeld surface analyses of (-hexyl--methyl-dithio-carbamato-κ,')triphenyl-tin(IV) and [-methyl--(2-phenyl-ethyl)-dithio-carbamato-κ,']tri-phenyl-tin(IV).

The crystal and mol-ecular structures of two tri-phenyl-tin di-thio-carbamate compounds, . [Sn(CH)(CHNS)], (I), and [Sn(CH)(CHNS)], (II), are described. The di-thio-carbamate ligand in each mol-ecule coordinates in an asymmetric fashion resulting in heavily distorted tetra-hedral CS coordin-ation geometries for the Sn atoms, with the distortions traced to the close approach of the non-coordinating thione-S atom.

Crystal structures and Hirshfeld surface analyses of bis-[,-bis-(2-meth-oxy-eth-yl)di-thio-carbamato-κ,']di--butyl-tin(IV) and [-(2-meth-oxy-eth-yl)--methyl-dithio-carbamato-κ,']tri-phenyl-tin(IV).

The crystal and mol-ecular structures of the two title organotin di-thio-carbamate compounds, [Sn(CH)(CHNOS)], (I), and [Sn(CH)(CHNOS)], (II), are described. Both structures feature asymmetrically bound di-thio-carbamate ligands leading to a skew-trapezoidal bipyramidal geometry for the metal atom in (I) and a distorted tetra-hedral geometry in (II). The complete mol-ecule of (I) is generated by a crystallographic twofold axis (Sn site symmetry 2).

Di--butyl-bis-[-(2-meth-oxy-eth-yl)--methyl-dithio-carbamato-κ,']tin(IV): crystal structure and Hirshfeld surface analysis.

The complete mol-ecule of the title compound, [Sn(CH)(CHNOS)], is generated by a crystallographic mirror plane, with the Sn atom and the two inner methyl-ene C atoms of the butyl ligands lying on the mirror plane; statistical disorder is noted in the two terminal ethyl groups, which deviate from mirror symmetry. The di-thio-carbamate ligand coordinates to the metal atom in an asymmetric mode with the resulting CS donor set defining a skew trapezoidal bipyramidal geometry; the -butyl groups are disposed to lie over the longer Sn-S bonds. Supra-molecular chains aligned along the -axis direction and sustained by methyl-ene-C-H⋯S(weakly coordinating) inter-actions feature in the mol-ecular packing.

[-Benzyl--(2-phenyl-eth-yl)di-thio-carbamato-κ,']tri-phenyl-tin(IV) and [bis-(2-meth-oxy-eth-yl)di-thio-carbamato-κ,']tri-phenyl-tin(IV): crystal structures and Hirshfeld surface analysis.

The crystal and mol-ecular structures of two tri-phenyl-tin di-thio-carbamates, [Sn(CH)(CHNS)], (I), and [Sn(CH)(CHNOS)], (II), are described. In (I), the di-thio-carbamate ligand coordinates the Sn atom in an asymmetric manner, leading to a highly distorted trigonal-bipyramidal coordination geometry defined by a CS donor set with the weakly bound S atom approximately to one of the -C atoms. A similar structure is found in (II), but the di-thio-carbamate ligand coordinates in an even more asymmetric fashion.

Distinct coordination geometries in bis-[N,N-bis-(2-meth-oxy-eth-yl)di-thio-carbamato-κ(2) S,S']di-phenyltin(IV) and bis-[N-(2-meth-oxy-eth-yl)-N-methyl-dithio-carbamato-κ(2) S,S']di-phenyl-tin(IV): crystal structures and Hirshfeld surface analysis.

The crystal and mol-ecular structures of two di-phenyl-tin bis-(di-thio-carbamate)s, [Sn(C6H5)2(C5H10NOS2)2], (I), and [Sn(C6H5)2(C7H14NO2S2)2], (II), are described. In (I), in which the metal atom lies on a twofold rotation axis, the di-thio-carbamate ligand coordinates with approximately equal Sn-S bond lengths and the ipso-C atoms of the Sn-bound phenyl groups occupy cis-positions in the resulting octa-hedral C2S4 donor set. A quite distinct coordination geometry is noted in (II), arising as a result of quite disparate Sn-S bond lengths.