French-Canadian families from Saguenay-Lac-Saint-Jean: a new founder population for APECED.

Purpose: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is more prevalent in some founder populations, but relatively unexplored in Canada. This study aimed at investigating the French-Canadian patients through phenotypic and genotypic characterization.

Method: Phenotype and demographic characterization were done for 12 affected individuals belonging to eight unrelated families.

Reduced endogenous pain inhibition in adolescent girls with chronic pain.

Background and aims Chronic pain is affecting a growing number of individuals including adolescents. Different endogenous pain inhibitory systems could confer protection against development of chronic pain. Decreased pain perception can be observed following intense pain (i.