Publications by authors named "Raphael Oladokun"
Article Synopsis
- Peripheral blood mononuclear cells (PBMCs) are immune cells derived from hematopoietic stem cells that play a key role in identifying signs of infections and abnormal cells related to diseases like cancer.
- Interactions between PBMCs and cancer cells can lead to changes in the PBMC composition, which can be detected using dielectrophoresis (DEP) for potential early breast cancer diagnosis.
- The study found significant differences in dielectric properties between PBMCs from cancerous mice and those from healthy controls, indicating that these properties may be useful for non-invasive cancer detection methods.
Dielectrophoresis (DEP) is widely utilized for trapping and sorting various types of cells, including live and dead cells and healthy and infected cells. This article focuses on the dielectric characterization of erythrocytes (red blood cells or RBCs) by quantifying DEP crossover frequency using a novel point-and-planar microwell device platform. Numerical simulations using COMSOL Multiphysics software demonstrate that the distribution of the DEP force is influenced by factors such as the shape of the point electrode, spacing between the point and planar electrodes, and the type of bioparticle being investigated.
View Article and Find Full Text PDFCoinfection with the tick-transmitted pathogen Babesia spp. is becoming a serious health problem because of the erythrocyte invasion through Ixodes scapularis tick. The transmission of this protozoan by blood transfusion often results in high morbidity and mortality in recipients.
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