Publications by authors named "Raphael O Anyango"

Article Synopsis
  • * A machine learning approach was applied using data from the VIDA and EFGH-Shigella studies in rural Kenya to create predictive models for LGF among children aged 6-35 months, encompassing 65 potential predictors including demographic and health-related factors.
  • * The models showed a prevalence of LGF at 16.9% and 22.4% in different cohorts, with the gradient boosting model providing the best prediction accuracy, demonstrating its usefulness in identifying at-risk children for targeted healthcare interventions
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Background: Although is an important cause of diarrhea in Kenyan children, robust research platforms capable of conducting incidence-based estimates and eventual targeted clinical trials are needed to improve -related outcomes in children. Here, we describe characteristics of a disease surveillance platform whose goal is to support incidence and consequences of diarrhea as part of multicounty surveillance aimed at preparing sites and assembling expertise for future vaccine trials.

Methods: We mobilized our preexisting expertise in shigellosis, vaccinology, and diarrheal disease epidemiology, which we combined with our experience conducting population-based sampling, clinical trials with high (97%-98%) retention rates, and healthcare utilization surveys.

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