Scaling Law for Kasha's Rule in Photoexcited Molecular Aggregates.

We study the photophysics of molecular aggregates from a quantum optics perspective, with emphasis on deriving scaling laws for the fast nonradiative relaxation of collective electronic excitations, referred to as Kasha's rule. Aggregates exhibit an energetically broad manifold of collective states with delocalized electronic excitations originating from near-field dipole-dipole exchanges between neighboring monomers. Photoexcitation at optical wavelengths, much larger than the monomer-monomer average separation, addresses almost exclusively symmetric collective states, which for an arrangement known as H-aggregate show an upward hypsochromic shift.

Optical Properties of Concentric Nanorings of Quantum Emitters.

A ring of sub-wavelength spaced dipole-coupled quantum emitters features extraordinary optical properties when compared to a one-dimensional chain or a random collection of emitters. One finds the emergence of extremely subradiant collective eigenmodes similar to an optical resonator, which features strong 3D sub-wavelength field confinement near the ring. Motivated by structures commonly appearing in natural light-harvesting complexes (LHCs), we extend these studies to stacked multi-ring geometries.

Probing pain aversion in rats with the "Heat Escape Threshold" paradigm.

The aversive aspect of pain constitutes a major burden faced by pain patients. This has been recognized by the pain research community, leading to the development of novel methods focusing on affective-motivational behaviour in pain model animals. The most common tests used to assess pain aversion in animals require cognitive processes, such as associative learning, complicating the interpretation of results.

GABAergic CaMKIIα+ Amygdala Output Attenuates Pain and Modulates Emotional-Motivational Behavior via Parabrachial Inhibition.

Pain and emotion are strongly regulated by neurons in the central nucleus of the amygdala (CeA), a major output of the limbic system; yet, the neuronal signaling pathways underlying this modulation are incompletely understood. Here, we characterized a subpopulation of CeA neurons that express the CaMKIIα gene (CeA neurons) and project to the lateral parabrachial nucleus (LPBN), a brainstem region known for its critical role in distributing nociceptive and other aversive signals throughout the brain. In male Sprague Dawley rats, we show that CeA-LPBN neurons are GABAergic and mostly express somatostatin.

Efficient nano-photonic antennas based on dark states in quantum emitter rings.

Nanoscopic arrays of quantum emitters can feature highly sub-radiant collective excitations with a lifetime exponentially growing with emitter number. Adding an absorptive impurity as an energy dump in the center of a ring shaped polygon allows to exploit this feature to create highly efficient single photon antennas. Here among regular polygons with an identical center absorbing emitter, a nonagon exhibits a distinct optimum of the absorption efficiency.

Nanoscale Coherent Light Source.

A laser is composed of an optical resonator and a gain medium. When stimulated emission dominates mirror losses, the emitted light becomes coherent. We propose a new class of coherent light sources based on wavelength sized regular structures of quantum emitters whose eigenmodes form high-Q resonators.

Towards functional selectivity for α6β3γ2 GABA receptors: a series of novel pyrazoloquinolinones.

Background And Purpose: The GABA receptors are ligand-gated ion channels, which play an important role in neurotransmission. Their variety of binding sites serves as an appealing target for many clinically relevant drugs. Here, we explored the functional selectivity of modulatory effects at specific extracellular α+/β- interfaces, using a systematically varied series of pyrazoloquinolinones.

Molecular tools for GABA receptors: High affinity ligands for β1-containing subtypes.

γ-Aminobutyric acid type A (GABA) receptors are pentameric GABA-gated chloride channels that are, in mammalians, drawn from a repertoire of 19 different genes, namely α1-6, β1-3, γ1-3, δ, ε, θ, π and ρ1-3. The existence of this wide variety of subunits as well as their diverse assembly into different subunit compositions result in miscellaneous receptor subtypes. In combination with the large number of known and putative allosteric binding sites, this leads to a highly complex pharmacology.