Publications by authors named "Raphael Gries"
Article Synopsis
- Drug-resistant Mycobacterium tuberculosis is a significant public health issue, necessitating innovative strategies alongside traditional treatments.
- Researchers discovered an oxadiazole compound (S3) that inhibits the ESX-1 secretion system, reducing the virulence and intracellular growth of Mtb.
- S3 not only impairs Mtb's ability to infect macrophages but also enhances the effectiveness of the prodrug ethionamide, demonstrating the potential for dual-action treatment approaches against tuberculosis.
Characterization of Two Novel Inhibitors of the Mycobacterium tuberculosis Cytochrome Complex.
Antimicrob Agents Chemother
July 2023
Drug-resistant tuberculosis is a global health care threat calling for novel effective treatment options. Here, we report on two novel cytochrome inhibitors (MJ-22 and B6) targeting the Mycobacterium tuberculosis respiratory chain with excellent intracellular activities in human macrophages. Both hit compounds revealed very low mutation frequencies and distinct cross-resistance patterns with other advanced cytochrome inhibitors.
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