Publications by authors named "Raphael El-Bekri Saudain"
Article Synopsis
- The text discusses the significance of lipophilicity in drug development, highlighting how structural modifications, especially through fluorine introduction, can optimize both bioactivity and lipophilicity of orally bioavailable drugs.
- It emphasizes the importance of studying fluorinated compounds' octanol-water partition coefficients to enhance understanding of how fluorine affects lipophilicity, which is crucial for computational modeling.
- The findings reveal that skipped fluorination is more effective in reducing log values compared to single or vicinal fluorination, and also detail the efficient synthesis of these compounds, some of which can be made enantioselective.
