Automated Classification of Physiologic, Glaucomatous, and Glaucoma-Suspected Optic Discs Using Machine Learning.

In order to generate a machine learning algorithm (MLA) that can support ophthalmologists with the diagnosis of glaucoma, a carefully selected dataset that is based on clinically confirmed glaucoma patients as well as borderline cases (e.g., patients with suspected glaucoma) is required.

Quantitative Analysis of Retinal Perfusion in Patients with Frontotemporal Dementia Using Optical Coherence Tomography Angiography.

Background: Optical coherence tomography angiography (OCT-A) provides detailed visualization of the perfusion of the vascular network of the eye. While in other forms of dementia, such as Alzheimer's disease and mild cognitive impairment, reduced retinal perfusion was frequently reported, data of patients with frontotemporal dementia (FTD) are lacking.

Objective: Retinal and optic nerve head perfusion was evaluated in patients with FTD with OCT-A.

Accuracy of Bruch's membrane opening minimum rim width and retinal nerve fiber layer thickness in glaucoma diagnosis depending on optic disc size.

Background/aim: The aim of this paper is to compare retinal nerve fiber layer thickness (RNFL) and Bruch's membrane opening-based minimum rim width (BMO-MRW) in terms of their performance in detecting early and moderate/advanced glaucoma using receiver operating characteristics (ROC) analysis and the classification using the 5th percentile as a cut-off.

Methods: One hundred eyes from 100 patients with early glaucoma (mean deviation (MD): < -5.0 dB) and 100 eyes from 100 patients with moderate/advanced glaucoma (MD: > -5.

Submacular Hemorrhages Show No Significant Seasonal Variations in a European Cohort.

The aim of the article is to investigate the seasonality of acute submacular hemorrhages (SMHs) in a European population and analyze the influence of the seasons, arterial hypertension, and intake of anticoagulatory/antiplatelet (AC/AP) medication on hemorrhage size. This retrospective, monocentric study included 164 eyes of 164 patients treated for acute SMH at the University Hospital Münster, Germany, between 1 January 2016 and 31 December 2021. Data on the day of occurrence, hemorrhage size, and general patient characteristics were recorded.

Influence of Cilioretinal Arteries on Flow Density in Glaucoma Patients Measured Using Optical Coherence Tomography Angiography.

It has long been speculated whether the presence of a cilioretinal artery (CRA) can influence the development of glaucomatous damage in patients with open-angle glaucoma. Studies involving healthy patients have shown a change in flow density (FD) depending on the presence of a CRA. Similarly, studies that compared the optical coherence tomography angiography (OCTA) results of healthy controls and glaucoma cohorts identified a reduction in FD in certain retinal layers for glaucoma patients.

Discriminating Healthy Optic Discs and Visible Optic Disc Drusen on Fundus Autofluorescence and Color Fundus Photography Using Deep Learning-A Pilot Study.

The aim of this study was to use deep learning based on a deep convolutional neural network (DCNN) for automated image classification of healthy optic discs (OD) and visible optic disc drusen (ODD) on fundus autofluorescence (FAF) and color fundus photography (CFP). In this study, a total of 400 FAF and CFP images of patients with ODD and healthy controls were used. A pre-trained multi-layer Deep Convolutional Neural Network (DCNN) was trained and validated independently on FAF and CFP images.

SALUS-a non-inferiority trial to compare self-tonometry in glaucoma patients with regular inpatient intraocular pressure controls: study design and set-up.

Purpose: The SALUS study aims to improve the healthcare situation for glaucoma patients in Germany. In order to detect diurnal intraocular pressure (IOP) fluctuations, inpatient monitoring of IOP in an eye hospital for a minimum of 24 h is the current standard. SALUS assesses the benefits of a new form of outpatient care, where IOP can be measured by the patients themselves at home using a self-tonometer.

[Corneal epithelial thickness in keratoconus patients compared to healthy controls].

Background: In keratoconus (KC) a progressive deformation and thinning of the cornea occurs. In contrast to Scheimpflug-based examinations, optical coherence tomography (OCT) can precisely measure the corneal layers separately, allowing separate analyses of corneal epithelial and corneal stromal thicknesses.

Aim Of This Work: The aim of this work was to analyze the corneal epithelial thickness measured by optical coherence tomography (OCT) in patients with KC in comparison to the corneal epithelial thickness in healthy subjects.

Optimizing intraocular lens power calculation using adjusted conventional keratometry for cataract surgery combined with Descemet membrane endothelial keratoplasty.

Purpose: To evaluate the utility of intraocular lens (IOL) power calculation using adjusted conventional keratometry (K) according to postoperative posterior to preoperative anterior corneal curvature radii (PPPA) ratio for eyes with Fuch's dystrophy undergoing cataract surgery combined with Descemet membrane endothelial keratoplasty (triple DMEK).

Methods: A fictitious refractive index (FRI) was determined (Pentacam HR®) based on the PPPA ratio in 50 eyes undergoing triple DMEK. Adjusted corneal power was calculated in every eye using adjusted K values: K values determined by the IOLMaster were converted to adjusted anterior corneal radius using the mean FRI.

Ocular perfusion in patients with reduced left ventricular ejection fraction measured by optical coherence tomography angiography.

Aims: The aim of this study is to evaluate retinal and optic nerve head (ONH) perfusion in patients with systolic chronic heart failure (CHF) compared to healthy control subjects.

Methods: Twenty-seven eyes of 27 patients with CHF (study group) and 31 eyes of 31 healthy subjects (control group) were prospectively included in this study. CHF Patients had a left ventricular ejection fraction (LVEF) < 50% and were classified by New York Heart Association (NYHA) class.

CILIORETINAL ARTERIES INFLUENCE OPTIC NERVE HEAD, PERIPAPILLARY, AND MACULAR VESSEL DENSITIES IN HEALTHY EYES: An Optical Coherence Tomography Angiography Study.

Background/purpose: To analyze the influence of a cilioretinal artery (CRA) on macular and peripapillary vessel density in healthy eyes as measured using optical coherence tomography angiography.

Methods: A total of 83 eyes of 83 patients were included in this study. Optical coherence tomography angiography was performed using the RTVue XR Avanti with AngioVue (Optovue Inc).

Global multi-site, prospective analysis of cataract surgery outcomes following ICHOM standards: the European CAT-Community.

Purpose: To evaluate in a large sample of patients from 10 different European centers the results of cataract surgery, characterizing the relationship between patient-reported outcomes (PROMs) and clinician-reported outcome measures (CROMs).

Methods: Prospective non-interventional multicenter observational descriptive study analyzing the clinical outcomes of a total of 3799 cases undergoing cataract surgery (mean age: 72.7 years).

[Change of corneal radii after Descemet membrane endothelial keratoplasty measured by optical coherence tomography and Scheimpflug tomography].

Background: The aim of the study was to compare the measurement of corneal radii using Scheimpflug tomography (Pentacam®, Oculus, Wetzlar, Germany) and optical coherence tomography (OCT, Optovue® XR-Avanti, Fremont, CA, USA) in eyes of patients with Fuchs' endothelial dystrophy (FED) before and after Descemet membrane endothelial keratoplasty (DMEK).

Material And Methods: In a retrospective analysis 35 eyes with (FED) that underwent DMEK were included. Pentacam® and Optovue® corneal measurements were performed preoperatively and at least 3 months postoperatively.

Assessing the validity of corneal power estimation using conventional keratometry for intraocular lens power calculation in eyes with Fuch's dystrophy undergoing Descemet membrane endothelial keratoplasty.

Purpose: The present retrospective study was designed to test the hypothesis that the postoperative posterior to preoperative anterior corneal curvature radii (PPPA) ratio in eyes with Fuch's dystrophy undergoing Descemet membrane endothelial keratoplasty (DMEK) is significantly different to the posterior to anterior corneal curvature radii (PA) ratio in virgin eyes and therefore renders conventional keratometry (K) and the corneal power derived by it invalid for intraocular lens (IOL) power calculation.

Methods: Measurement of corneal parameters was performed using Scheimpflug imaging (Pentacam HR, Oculus, Germany). In 125 eyes with Fuch's dystrophy undergoing DMEK, a fictitious keratometer index was calculated based on the PPPA ratio.

Using the posterior to anterior corneal curvature radii ratio to minimize the risk of a postoperative hyperopic shift after Descemet membrane endothelial keratoplasty.

Purpose: To evaluate different corneal parameters in identifying patients at risk of a hyperopic shift after (DMEK).

Methods: This retrospective study included 92 eyes of patients with FECD after DMEK surgery. Pachymetry parameters, various tomographic parameters and densitometry values before and after DMEK were determined using a rotating Scheimpflug system (Pentacam HR, Oculus).

[Importance of Cryotherapy for Eyelid Papillomas].

Purpose: Cryotherapy as a destructive procedure is an important alternative to the surgical excision of eyelid tumors.

Methods: We report our own experiences in the cryotherapy of large upper eyelid papillomas using spray- and contact-freezing.

Results/conclusions: Cryotherapy gave excellent results in the treatment of unusually large papillomas.

Bifocal nondiffractive intraocular lens for enhanced depth of focus in correcting presbyopia: Clinical evaluation.

Purpose: To assess the clinical outcomes and patient satisfaction after bilateral cataract surgery with implantation of a bifocal refractive enhanced depth of focus intraocular lens (IOL) with a low near addition (add).

Setting: Department of Ophthalmology, Ludwig-Maximilians-University Munich, Munich, Germany.

Design: Prospective longitudinal case series.

Adapting Guidelines for Google Glass: the Case of Pediatric CPR.

Early recognition and management of patients at risk and more aggressive implementation of evidence-based resuscitation guidelines play a role to the reduction of patients' mortality. If, in paediatric emergency department, the proper adherence to the paediatric cardiac arrest guidelines is critical to increase the chance of survival, this adherence is unfortunately often suboptimal. Connected glasses, such as the Google Glass, offer an interesting support to provide guidelines at the point of care.

Opportunities and limitations in using google glass to assist drug dispensing.

The administration of intravenous drugs is a significant source of medical errors. Protocol based care are have been demonstrated to be an efficient way to favor best practices and to avoid simple errors such as those related to expiration date, hygiene regulation among other. The recent availability of the Google Glass, a hands free wearable device offers new opportunities to access care protocols at patients' bedside.