Chemotherapy-associated steatohepatitis induced by irinotecan: a novel animal model.

Purpose: Nonalcoholic steatohepatitis (NASH) has been associated with irinotecan (IRI)-based cancer chemotherapy regimens. The purpose of this study was to propose and test a consistent model of IRI-induced NASH, filling a gap in the medical literature.

Methods: Swiss male mice were distributed in groups (n = 8) and injected with saline (5 mL/kg, i.