Publications by authors named "Raphael Boneberg"
Article Synopsis
- - Obstructive sleep apnea (OSA) leads to higher insulin resistance through mechanisms not entirely understood, and these effects are amplified by hypoxia-related increases in free fatty acids (FFAs) like palmitic acid (PA) during the night.
- - A study compared lipid levels and muscle fiber types in 26 male OSA patients and 23 healthy controls, finding that OSA patients had significantly higher levels of intramyocellular (IMCL) and extramyocellular lipids (EMCL) and FFAs, particularly in nonobese individuals.
- - After treatment with continuous positive airway pressure (CPAP), patients showed a significant decrease in EMCL and a trend towards lower IMCL and total FFAs
Obstructive sleep apnea (OSA) independent of obesity (OBS) imposes severe cardiovascular risk. To what extent plasma cystine concentration (CySS), a novel pro-oxidative vascular risk factor, is increased in OSA with or without OBS is presently unknown. We therefore studied CySS together with the redox state and precursor amino acids of glutathione (GSH) in peripheral blood mononuclear cells (PBMC) in untreated male patients with OSA (apnea-hypopnea-index (AHI) > 15 h, = 28) compared to healthy male controls ( = 25) stratifying for BMI ≥ or < 30 kg m.
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