Osteochondrolipoma of the submandibular region: a case report and review of the literature.

Lipoma is an extremely common and ubiquitous benign soft tissue tumor composed of mature adipose tissue, with frequent differentiation towards other mesenchymal elements such as blood vessels, fibrous tissue, or muscle. They are typically slow-growing, encapsulated, superficial or deep, and have a wide range in size depending on their location. The presence of cartilage or bone is very rare, with most reported cases in the head and neck area.

Atorvastatin treatment is effective when used in combination with mefloquine in an experimental cerebral malaria murine model.

Background: One of the major complications of Plasmodium falciparum infection is cerebral malaria (CM), which causes one million deaths worldwide each year, results in long-term neurological sequelae and the treatment for which is only partially effective. Statins are recognized to have an immunomodulatory action, attenuate sepsis and have a neuroprotective effect. Atorvastatin (AVA) has shown in vitro anti-malarial activity and has improved the activity of mefloquine (MQ) and quinine.

Primitive neuroectodermal tumor of the stomach.

Ewing sarcoma/primitive neuroectodermal tumor is classically a tumor of the soft tissue or bone in children and young adults, but several cases have been described in patients of all ages. Within the last decade, the clinicopathologic spectrum of Ewing sarcoma/primitive neuroectodermal tumor has been markedly expanded by recognition that the tumor may also have a visceral origin. We describe a case of primitive neuroectodermal tumor arising in the stomach of a 66-year-old woman.

[Peripheral ameloblastic fibrosarcoma].

We describe the clinicopathological features of a peripheral ameloblastic fibrosarcoma (PAFS) diagnosed in a 89-years-old man with a past history of recurrent peripheral ameloblastoma. Like other peripheral odontogenic tumors, PAFS shows histological features comparable to those of the central intraosseous form, with (fibro)sarcomatous proliferation associated to benign-appearing ameloblastomatous areas. The differential diagnosis must be made with a low-grade spindle ameloblastic carcinoma and with a collision tumor (a non odontogenic sarcoma associated with a recurrent ameloblastoma).