Publications by authors named "Rao-Kaijuan Wang"
Article Synopsis
- Delayed healing of infected wounds is due to excessive reactive oxygen species (ROS), leading to tissue damage and a lack of oxygen, which fuels inflammation.
- Existing treatments like hyperbaric oxygen therapy and antibiotics do not sustain oxygen delivery or prevent infections effectively.
- This study introduces a new hydrogel dressing that scavenges ROS and releases oxygen, enhancing cell survival, promoting healing, and providing drug-free infection resistance by modulating the immune response in wounds.
Current approaches to treating inflammatory bowel disease focus on the suppression of overactive immune responses, the removal of reactive intestinal oxygen species, and regulation of the intestinal flora. However, owing to the complex structure of the gastrointestinal tract and the influence of mucus, current small-molecule and biologic-based drugs for treating colitis cannot effectively act at the site of colon inflammation, and as a result, they tend to exhibit low efficacies and toxic side effects. In this study, nanogel-based multistage NO delivery microcapsules are developed to achieve NO release at the inflammation site by targeting the inflammatory tissues using the nanogel.
View Article and Find Full Text PDFMacrophages are highly heterogeneous and exhibit a diversity of functions and phenotypes. They can be divided into pro-inflammatory macrophages (M1) and anti-inflammatory macrophages (M2). Diabetic wounds are characterized by a prolonged inflammatory phase and difficulty in healing due to the accumulation of pro-inflammatory (M1) macrophages in the wound.
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