A history of polymyalgia rheumatica: a narrative review.

Polymyalgia rheumatica (PMR) is characterized by stiffness and pain in the shoulders, hips and neck and presents most commonly in the eighth decade. It can coexist with giant cell arteritis and the two diseases may share some pathophysiological mechanisms. This narrative review considers present-day ideas about PMR in a historical context, from the first names and descriptions of this disease entity, via successive generations of classification criteria sets, and finally to implications for clinical diagnosis.

Characteristics of surface modified sugarcane bagasse cellulose: application of esterification and oxidation reactions.

Research on polymer matrix composites has become increasingly important in both the academic and industrial sectors. The study of polymer-natural fiber composites, known for their eco-friendly properties, has gained significance. Sugarcane bagasse fibers, abundant as discarded agricultural byproducts, offer improved properties such as density, rigidity, strength, and cost-effectiveness, enhancing sustainability.

Cancer Worry and Fatalism at the Intersection of Race and Hearing Status.

Introduction: The deaf and hard of hearing (DHH) community experiences lower cancer screening rates than the general population. Cancer worry and fatalism can influence cancer screening, along with race, and the interaction of intrinsic factors with DHH health behavior needs to be investigated.

Objectives: The study examines the association of the intersection of race and hearing status with cancer worry and fatalism.

Spontaneous Coronary Artery Dissection: A Case Series and Review of the Literature.

Although previously considered rare, spontaneous coronary artery dissection (SCAD) is increasingly recognized as an important cause of myocardial infarction in young women. We present three unique cases of SCAD: A 46-year-old woman with a history of trigeminal neuralgia and anxiety presenting elevated troponin-I and chest pain. A 36-year-old woman with recent miscarriage presenting with diffuse T wave inversions and elevated troponin-I.

Utility of the AngelMed Guardian System in myocardial bridging: a case report.

Background: Myocardial bridging (MB) is a known congenital anomaly in which a segment of the coronary artery transverses from the epicardium through the myocardium. MB may clinically manifest as recurrent angina, acute coronary syndrome, ventricular dysrhythmia, and even sudden cardiac death. On electrocardiogram (EKG), MB can present with findings consistent with significant ST-segment changes.

Optimizing secure multimedia communication in embedded systems a parallel convolutional neural network approach to RIS and D2D resource allocation.

With the rapid development of Internet of Things (IoT) services, technologies that leverage multimedia computer communication for information sharing in embedded systems have become a research focus. To address the challenges of low spectral efficiency and poor network flexibility in multimedia computer communications, this paper proposes a resource allocation scheme based on parallel Convolutional Neural Network (CNN). The scheme optimizes the base station beamforming vector and the Reconfigurable Intelligent Surface (RIS) phase shifts to maximize the secure transmission rate for cellular users (CUs), while ensuring normal and secure communication for device-to-device (D2D) users.

An uncommon cause of a common disease: a case report of a rare cause of hypertension.

Background: Severe hypertension in young patients presents a significant diagnostic dilemma, and treatment can often be codified. Therefore, it is crucial to diagnose these cases for probable secondary hypertension. Common causes of secondary hypertension include large vessel vasculitis, renal artery stenosis, coarctation of the aorta, and endocrine disorders.

Pediatric Long COVID Subphenotypes: An EHR-based study from the RECOVER program.

Pediatric Long COVID has been associated with a wide variety of symptoms, conditions, and organ systems, but distinct clinical presentations, or subphenotypes, are still being elucidated. In this exploratory analysis, we identified a cohort of pediatric (age <21) patients with evidence of Long COVID and no pre-existing complex chronic conditions using electronic health record data from 38 institutions and used an unsupervised machine learning-based approach to identify subphenotypes. Our method, an extension of the Phe2Vec algorithm, uses tens of thousands of clinical concepts from multiple domains to represent patients' clinical histories to then identify groups of patients with similar presentations.

Preanalytical Phase Tumor Contaminants in Intraoperative Margins From Transoral Robotic Surgeries.

Context.—: Tumor contaminants were incidentally noted in frozen section margins of oropharyngeal squamous cell carcinoma.

Objective.

Dual regulation of IP receptors by IP and PIP controls the transition from local to global Ca signals.

The spatial organization of inositol 1,4,5-trisphosphate (IP)-evoked Ca signals underlies their versatility. Low stimulus intensities evoke Ca puffs, localized Ca signals arising from a few IP receptors (IPRs) within a cluster tethered beneath the plasma membrane. More intense stimulation evokes global Ca signals.

Causes, Diagnostic Testing, and Treatments Related to Clinical Deterioration Events Among High-Risk Ward Patients.

Importance: Timely intervention for clinically deteriorating ward patients requires that care teams accurately diagnose and treat their underlying medical conditions. However, the most common diagnoses leading to deterioration and the relevant therapies provided are poorly characterized.

Objectives: We aimed to determine the diagnoses responsible for clinical deterioration, the relevant diagnostic tests ordered, and the treatments administered among high-risk ward patients using manual chart review.

Near-infrared activated liposomes for neuroprotection in glaucoma.

Neurodegenerative diseases have a profound impact on vision, leading to conditions such as glaucoma, optic neuropathy, and diabetic retinopathy, affecting millions worldwide. These diseases are characterized by the degeneration of retinal ganglion cells (RGCs), resulting in a progressive loss of visual acuity and field, with the threat of irreversible blindness. However, existing treatments, such as eye drops, direct injections, and laser surgeries face significant challenges due to limited efficacy and potential infection.

Evolving intellectual property landscape for AI-driven innovations in the biomedical sector: opportunities in stable IP regime for shared success.

Artificial Intelligence (AI) has revolutionized the biomedical sector in advanced diagnosis, treatment, and personalized medicine. While these AI-driven innovations promise vast benefits for patients and service providers, they also raise complex intellectual property (IP) challenges due to the inherent nature of AI technology. In this review, we discussed the multifaceted impact of AI on IP within the biomedical sector, exploring implications in areas like drug research and discovery, personalized medicine, and medical diagnostics.

Breathlessness without borders: a call to action for global breathlessness research.

It is likely that the burden of breathlessness in low and middle-income countries (LMICs) is much higher than has been estimated using calculations of disease burden and expected prevalence of the symptom. However, most breathlessness research has been conducted in high-income countries and may not be relevant to LMICs. To address this issue, we convened an international breathlessness and global health workshop.

Effect of Four Hemoglobin Transfusion Threshold Strategies in Patients With Acute Myocardial Infarction and Anemia : A Target Trial Emulation Using MINT Trial Data.

Background: The optimal hemoglobin threshold to guide red blood cell (RBC) transfusion for patients with acute myocardial infarction (MI) and anemia is uncertain.

Objective: To estimate the efficacy of 4 individual hemoglobin thresholds (<10 g/dL [<100 g/L], <9 g/dL [<90 g/L], <8 g/dL [<80 g/L], and <7 g/dL [<70 g/L]) to guide transfusion in patients with acute MI and anemia.

Design: Prespecified secondary analysis of the MINT (Myocardial Ischemia and Transfusion) trial using target trial emulation methods.