Publications by authors named "Rao Qian"
A novel gold(I)/Brønsted acid relay catalysis enabling azofuran activation to induce annulative rearrangement from 3-yne-1,2-diols and aryldiazonium tetrafluoroborates is reported, producing a series of furan-2-yl-substituted pyrrol-2-ones bearing a quaternary carbon center with good yields. Exchanging aryldiazonium tetrafluoroborate for azofuran led to skeletally identical but substituent-diverse furan-2-yl-containing pyrrol-2-ones with good yields, supporting the key azofuran activation and annulative rearrangement by gold/Brønsted acid relay catalysis.
View Article and Find Full Text PDFAim: The aim of the study is to test a moderated mediation model that focuses on job resources mediating the relationship between organizational climate and nurse engagement in the long-term care facilities and emotional intelligence moderates this mediated relationship.
Background: The shortage of nurses is a global problem, especially in the long-term care facilities. We integrated and extended past research exploring the influence of nurse engagement and constructed a model of nurse engagement in the long-term care facilities.
Purpose: Patients undergoing maintenance hemodialysis (MHD) frequently experience chronic pain, which can severely affect their quality of life (QOL). The objective of this study was to evaluate the prevalence of chronic pain in MHD patients and examine the factors associated with QOL.
Patients And Methods: A cross-sectional questionnaire-based survey was conducted between October 2020 and April 2021, 1204 MHD patients from nine hemodialysis units were screened for chronic pain in Chengdu, China, and 296 MHD patients with chronic pain were enrolled in this study.
Article Synopsis
- The text discusses a novel, eco-friendly method for creating varied heterocyclic compounds, specifically pyrano[3,4-]chromen-2-ones and pyrano[3,4-]quinolin-2-ones.
- This process involves a unique photocatalytic mechanism that combines multiple chemical reactions, including cyclization and substitution, starting from readily available 1,7-diynes and inexpensive CBrCl.
- A key feature of this reaction is the complete cleavage of carbon-halogen bonds, which facilitates the formation of two new ring structures, including a lactone, with water acting as the source of the ester oxygen.
A new and general photocatalytic Kharasch-type addition/1,5-(SN'')-substitution cascade of 1,7-diynes with alkyl halides such as BrCCl3 and CBr4 was reported for the first time, and used to produce 65 hitherto unreported β-gem-dihalovinyl ketones/aldehydes with moderate to excellent yields in a highly regioselective manner. This reaction tolerates a wide scope of substrates, which offers a green and efficient entry to fabricate synthetically important β-gem-dihalovinyl carbonyl scaffolds. Notably, the late-stage application of these resulting β-gem-dihalovinyl carbonyls shows high and unique reactivity profiles and demonstrates the versatility of their derivatization.
View Article and Find Full Text PDFBackground: Published studies on association between IL12B (G/A) rs10045431, (T/C)rs6887695 polymorphisms and inflammatory bowel disease (IBD) risk in Caucasian population have yielded conflicting results. The aim of this study was to potentially provide more reliable conclusions by conducting a meta-analysis.
Methods: Published studies concerned association between IL12B rs10045431, rs6887695 polymorphisms and IBD were searched from the Wiley Online Library, PubMed, Web of Science and the CNKI database.
Background: The results from previous studies on association between prostaglandin E receptor 4 (PTGER4) polymorphisms and inflammatory bowel disease (IBD) risk in Caucasian were conflict. The present study aimed to investigate the genetic association by conducting a meta-analysis.
Methods: Systematic literature search was conducted through Wiley Online Library, Chinese National Knowledge Infrastructure (CNKI), and PubMed databases.
Article Synopsis
- Calcium hydroxide has been a traditional pulpotomy agent, but its effectiveness is being compared to a new material called iRoot BP Plus, which is a calcium silicate-based bioactive ceramic known for its bioactivity and sealing capabilities.
- In a study with 205 permanent incisors that had complicated crown fractures, teeth were treated with either iRoot BP Plus or calcium hydroxide, and their progress was monitored over 12 to 24 months.
- Results showed that iRoot BP Plus had a higher success rate (99%) compared to calcium hydroxide (93%), suggesting that iRoot BP Plus could be a better option for pulpotomy in such cases, even though both materials were effective in forming reparative dentin bridges.
MicroRNAs (miRNAs) are involved in the progression of different types of cancers giving new hope for cancer treatment. The role and regulatory mechanism of microRNA‑187 (miR‑187) are largely unknown. In the present study, 74 patients with non‑small cell lung cancer (NSCLC) were selected.
View Article and Find Full Text PDFThe current study reports the case of a 68-year-old male who presented with a 4-month history of a painless slow-growing mass in the left parotid region. Magnetic resonance imaging revealed two independent, round lesions in the superficial and deep lobes of the parotid gland on the left side, respectively. A total parotidectomy was performed and basal cell adenomas (BCAs) were identified by histopathological examination.
View Article and Find Full Text PDFObjective: To screen the matrix and permeation enhancer of Duliang Patches.
Methods: Based on L9 (3(4)) orthogonal experimental design, the content of imperatorin of the release rate and transdermal osmolality were regarded as evaluation indexes to optimize the matrix and permeation enhancer of patches suing of Drug dissolution tester and Franz diffusion cell.
Results: The best prescriplion of sustained-release patch of Duliang was: the quality percentage content of the starch, sodium carboxymethyl cellulose, glycerin, azone, propylene glycol and PEG400 was 6%, 2%, 30%, 1%, 15% and 2.