Distance in depth: A comparison of explicit and implicit numerical distances in the horizontal and radial dimensions.

Numbers are a constant presence in our daily lives: A brain devoid of the ability to process numbers would not be functional in its external environment. Comparing numerical magnitudes is a fundamental ability that requires the processing of numerical distances. From magnitude comparison tasks, a comparison distance effect (DE) emerges: It describes better performance when comparing numerically distant rather than close numbers.

Ecological Meanings: A Consensus Paper on Individual Differences and Contextual Influences in Embodied Language.

Embodied theories of cognition consider many aspects of language and other cognitive domains as the result of sensory and motor processes. In this view, the appraisal and the use of concepts are based on mechanisms of simulation grounded on prior sensorimotor experiences. Even though these theories continue receiving attention and support, increasing evidence indicates the need to consider the flexible nature of the simulation process, and to accordingly refine embodied accounts.

White matter tract disconnection in Gerstmann's syndrome: Insights from a single case study.

It has been suggested that Gerstmann's syndrome is the result of subcortical disconnection rather than emerging from damage of a multifunctional brain region within the parietal lobe. However, patterns of white matter tract disconnection following parietal damage have been barely investigated. This single case study allows characterising Gerstmann's syndrome in terms of disconnected networks.

Cortical areas involved in grasping and reaching actions with and without visual information: An ALE meta-analysis of neuroimaging studies.

The functional specialization of the ventral stream in Perception and the dorsal stream in Action is the cornerstone of the leading model proposed by Goodale and Milner in 1992. This model is based on neuropsychological evidence and has been a matter of debate for almost three decades, during which the dual-visual stream hypothesis has received much attention, including support and criticism. The advent of functional magnetic resonance imaging (fMRI) has allowed investigating the brain areas involved in Perception and Action, and provided useful data on the functional specialization of the two streams.

Influences of hand action on the processing of symbolic numbers: A special role of pointing?

Embodied and grounded cognition theories state that cognitive processing is built upon sensorimotor systems. In the context of numerical cognition, support to this framework comes from the interactions between numerical processing and the hand actions of reaching and grasping documented in skilled adults. Accordingly, mechanisms for the processing of object size and location during reach and grasp actions might scaffold the development of mental representations of numerical magnitude.

A common neural substrate for number comparison, hand reaching and grasping: A SDM-PSI meta-analysis of neuroimaging studies.

The reliance of number processing on sensorimotor mechanisms involved in hand action has been extensively documented by behavioural studies. Nonetheless, where and how the computations of number and hand action interact in the brain has received limited attention. In this study we investigated the brain networks underlying symbolic number comparison and the hand action of reaching and grasping, capitalizing on functional imaging studies meta-analyzed with the seed-based d mapping with permutation of subject images meta-analytic method (SDM-PSI).

Effects of attentional shifts along the vertical axis on number processing: An eye-tracking study with optokinetic stimulation.

Previous studies suggest that associations between numbers and space are mediated by shifts of visuospatial attention along the horizontal axis. In this study, we investigated the effect of vertical shifts of overt attention, induced by optokinetic stimulation (OKS) and monitored through eye-tracking, in two tasks requiring explicit (number comparison) or implicit (parity judgment) processing of number magnitude. Participants were exposed to black-and-white stripes (OKS) that moved vertically (upward or downward) or remained static (control condition).

Individualized Prognostic Prediction of the Long-Term Functional Trajectory in Pediatric Acquired Brain Injury.

In pediatric acquired brain injury, heterogeneity of functional response to specific rehabilitation treatments is a key confound to medical decisions and outcome prediction. We aimed to identify patient subgroups sharing comparable trajectories, and to implement a method for the early prediction of the long-term recovery course from clinical condition at first discharge. 600 consecutive patients with acquired brain injury (7.

A multi-channel uncertainty-aware multi-resolution network for MR to CT synthesis.

Synthesising computed tomography (CT) images from magnetic resonance images (MRI) plays an important role in the field of medical image analysis, both for quantification and diagnostic purposes. Convolutional neural networks (CNNs) have achieved state-of-the-art results in image-to-image translation for brain applications. However, synthesising whole-body images remains largely uncharted territory involving many challenges, including large image size and limited field of view, complex spatial context, and anatomical differences between images acquired at different times.

Changes in electrophysiological static and dynamic human brain functional architecture from childhood to late adulthood.

This magnetoencephalography study aimed at characterizing age-related changes in resting-state functional brain organization from mid-childhood to late adulthood. We investigated neuromagnetic brain activity at rest in 105 participants divided into three age groups: children (6-9 years), young adults (18-34 years) and healthy elders (53-78 years). The effects of age on static resting-state functional brain integration were assessed using band-limited power envelope correlation, whereas those on transient functional brain dynamics were disclosed using hidden Markov modeling of power envelope activity.

Early intravenous iron administration in the Emergency Department reduces red blood cell unit transfusion, hospitalisation, re-transfusion, length of stay and costs.

Background: Moderate to severe iron deficiency anaemia is a common finding in patients admitted to the Emergency Department (ED). According to Patient Blood Management principles, intravenous iron should be the therapy of choice instead of blood transfusion for selected cases affected by chronic iron deficiency anaemia. However, this option is only rarely taken into account by physicians in the ED.

Automated postoperative muscle assessment of hip arthroplasty patients using multimodal imaging joint segmentation.

Background And Objective: In patients treated with hip arthroplasty, the muscular condition and presence of inflammatory reactions are assessed using magnetic resonance imaging (MRI). As MRI lacks contrast for bony structures, computed tomography (CT) is preferred for clinical evaluation of bone tissue and orthopaedic surgical planning. Combining the complementary information of MRI and CT could improve current clinical practice for diagnosis, monitoring and treatment planning.

Colours + Numbers differs from colours of numbers: cognitive and visual illusions in grapheme-colour synaesthesia.

This study investigates the bi-directionality of synaestesic experience by means of a flanked bisection paradigm in TT, a number-colour synaesthete. Previous studies have shown that bisection is shifted towards the larger digit flanker (e.g.

Simulating the hydrological response of a small tropical forest watershed (Mata Atlantica, Brazil) by the AnnAGNPS model.

Given the intrinsic hydrological cycle made of large input of water vapour and intense precipitation producing large volumes of water and sediment, modelling runoff and water losses in humid tropical watersheds is important for forest and water resources management. For instance, reliable simulations of the water cycle in such environments are a prerequisite for predictions of water quality, soil erosion and the climate change effects on water resources. The distributed parameter, physically based, continuous simulation, daily time step AnnAGNPS model, was implemented in almost completely forested (98% of its area, 0.

The consonant/vowel pattern determines the structure of orthographic representations in the left fusiform gyrus.

Recent findings demonstrated readers' sensitivity to the distinction between consonant and vowel letters. Especially, the way consonants and vowels are organised within written words determines their perceptual structure. The present work attempted to overcome two limitations of previous studies by examining the neurophysiological correlates of this perceptual structure through magnetoencephalography (MEG).

Hemispatial neglect and serial order in verbal working memory.

Working memory refers to our ability to actively maintain and process a limited amount of information during a brief period of time. Often, not only the information itself but also its serial order is crucial for good task performance. It was recently proposed that serial order is grounded in spatial cognition.

Effects of land use and seasonality on stream water quality in a small tropical catchment: The headwater of Córrego Água Limpa, São Paulo (Brazil).

Stream water quality is controlled by the interaction of natural and anthropogenic factors over a range of temporal and spatial scales. Among these anthropogenic factors, land cover changes at catchment scale can affect stream water quality. This work aims to evaluate the influence of land use and seasonality on stream water quality in a representative tropical headwater catchment named as Córrego Água Limpa (Sao Paulo, Brasil), which is highly influenced by intensive agricultural activities and urban areas.

Contribution of visuospatial attention, short-term memory and executive functions to performance in number interval bisection.

Number interval bisection consists of estimating the mid-number within a pair (1-9=>5). Healthy adults and right-brain damage patients can show biased performance in this task, underestimating and overestimating the mid-number, respectively. The role of visuospatial attention during this task, and its interplay with other cognitive abilities (e.

Order information in verbal working memory shifts the subjective midpoint in both the line bisection and the landmark tasks.

A largely substantiated view in the domain of working memory is that the maintenance of serial order is achieved by generating associations of each item with an independent representation of its position, so-called position markers. Recent studies reported that the ordinal position of an item in verbal working memory interacts with spatial processing. This suggests that position markers might be spatial in nature.

Voluntary eye movements direct attention on the mental number space.

Growing evidence suggests that orienting visual attention in space can influence the processing of numerical magnitude, with leftward orienting speeding up the processing of small numbers relative to larger ones and the converse for rightward orienting. The manipulation of eye movements is a convenient way to direct visuospatial attention, but several aspects of the complex relationship between eye movements, attention orienting and number processing remain unexplored. In a previous study, we observed that inducing involuntary, reflexive eye movements by means of optokinetic stimulation affected number processing only when numerical magnitude was task relevant (i.

Perceiving object dangerousness: an escape from pain?

A variety of studies showed that participants are facilitated when responding to graspable objects, while it has not been fully investigated what happens during interactions with graspable objects that are potentially dangerous. The present study focuses on the mechanisms underlying the processing of dangerous objects. In two experiments, we adopted a paradigm that has never been employed in this context, a bisection task.

Influence of numerical magnitudes on the free choice of an object position.

The link between numerical magnitude and mechanisms of spatial orienting has been underlined in an increasing number of studies. Similarly, the relationship between numerical magnitude and grasping actions has started to be investigated. The present study focuses on the influence of numerical magnitude processing in the free choice of the position of an object.

Exploiting illusory effects to disclose similarities in numerical and luminance processing.

Recent studies have suggested that numerical and physical magnitudes are similarly processed by a generalized magnitude system. The present study investigates the number-luminance interaction, taking advantage of illusory effects in a cued line bisection task with numerical or nonnumerical flankers and varying levels of luminance. The results showed that both dimensions influenced bisection performance.

Graspable objects shape number processing.

The field of numerical cognition represents an interesting case for action-based theories of cognition, since number is a special kind of abstract concept. Several studies have shown that within the parietal lobes adjacent neural regions code numerical magnitude and grasping-related information. This anatomical proximity between brain areas involved in number and sensorimotor processes may account for interactions between numerical magnitude and action.