Association of promoter methylation status of NRF2 and PNPLA3 genes in alcoholic liver disease.

Background: Alcoholic liver disease (ALD) is the leading cause of chronic liver disease. In the liver, metabolism of alcohol occurs through multiple mechanisms and it results in the generation of various toxic products. Multiple genetic causes have been identified that are associated with the development and progression of ALD.

Pharmacological assessment of the heartwood of Willd for antifungal potential.

As COVID-19 suppresses the immune system and those who have recovered from COVID-19 are at risk of developing mucormycosis or black fungus so there is a need to develop new antifungal strategies by the use of medicinal plants. Medicinal plants have always been a subject of interest for drug discovery, ethno-botany, traditional and indigenous medicines. One of the successful strategies for the investigation of new bioactive compounds from medicinal plants includes the screening of plant extract, fractions followed by the purification of the constituents and screening for biological activity.

Multifunctional Nanohybrid of Alumina and Indium Oxide Prepared Using the Atomic Layer Deposition Technique.

Developing new transparent conducting materials, especially those having flexibility, is of great interest for electronic applications. Here, our study on using the ozone-assisted atomic layer deposition (ALD) technique at a low temperature of 200 °C for making an ultrathin, transparent, flexible, and highly electroconducting nanohybrid of indium and aluminum oxides is introduced. Through various characterizations, measurements, and density functional theory-based calculations, excellent electrical conductivity (∼950 S cm), transparency (95% in the visible region), and flexibility (bendable angle of 130° for 10 000 cycles) of our nanohybrid oxide thin film with a total layer thickness below 15 nm (2-4 nm for alumina and 10 nm for indium oxide) have been revealed and discussed.

Controlled creation and annihilation of isolated robust emergent magnetic monopole like charged vertices in square artificial spin ice.

Magnetic analogue of an isolated free electric charge, i.e., a magnet with a single north or south pole, is a long sought-after particle which remains elusive so far.

Effect of Fe ion implantation on the thermoelectric properties and electronic structures of CoSb thin films.

In the present study, thin films of single-phase CoSb were deposited onto Si(100) substrates pulsed laser deposition (PLD) method using a polycrystalline target of CoSb. These films were implanted by 120 keV Fe-ions with three different fluences: 1 × 10, 2.5 × 10 and 5 × 10 ions per cm.

Growth of Wafer-Scale ReS with "Tunable" Geometry toward Electron Field-Emission Application.

Despite high potential, the promise of 2D materials has not been realized practically because of limits of tiny grown size and difficult manipulation of the active spot. The utilization of 2D layers is the ultimate approach, which should be supported by large-scale production. In this very first report, we demonstrate the wafer-scale production of ReS using the conventional sputtering method.

Outcome of a "modified brief intervention" program delivered at work place for a population with hazardous alcohol use.

Introduction: At the population level, screening and brief intervention (BI) is the most cost-effective method to reduce the burden of disease due to hazardous alcohol use. In delivering BI at individual level, trained workforce as well as time is a limiting factor. Hence, a study was conducted to assess the outcome of a "modified brief intervention" program delivered at workplace in a group setting for the participants identified with hazardous alcohol use pattern, as a secondary prevention measure.

Ocular Permeation and Sustained Anti-inflammatory Activity of Dexamethasone from Kaolin Nanodispersion Hydrogel System.

Purpose: Kaolin can adhere to the mucosa and protect it by absorbing toxins, bacteria, and viruses. Ocular delivery and anti-inflammatory activity of dexamethasone hydrogel system could be advantageous after kaolin incorporation.

Methods: Hydroxypropyl methylcellulose (HPMC) films of dexamethasone have been prepared without and with kaolin by solvent casting method.

Lifetime alcohol consumption and severity in alcohol dependence syndrome.

Introduction: Alcohol dependence syndrome is a major public health issue globally and is responsible for significant morbidity and mortality. The total dose of alcohol consumed has been linked to liver diseases, pancreatitis, and other alcohol-related medical consequences. However, this has not been studied in relation to severity of dependence; although it is well known that alcohol causes neuronal damage, which in turn potentiates dependence.

Strong uniaxial magnetic anisotropy in Co films on highly ordered grating-like nanopatterned Ge surfaces.

We present a systematic investigation on uniaxial magnetic anisotropy (UMA) in Co thin films induced by high aspect ratio nanopatterned anisotropic substrates. Self-organized long grating-like nanostructures, with extreme regularities, are fabricated on Ge surfaces using Au-ion implantation at room temperature. Subsequently deposition of Co films are carried out on the same at two different angles.

Ag nanoparticle decorated molybdenum oxide structures: growth, characterization, DFT studies and their application to enhanced field emission.

We report a simple single step growth of α-MoO structures and energetically suitable site specific Ag nanoparticle (NP) decorated α-MoO structures on varied substrates, having almost similar morphologies and oxygen vacancies. We elucidate possible growth mechanisms in light of experimental findings and density functional theory (DFT) calculations. We experimentally establish and verified by DFT calculations that the MoO(010) surface is a weakly interacting and stable surface compared to other orientations.

Gold-decorated highly ordered self-organized grating-like nanostructures on Ge surface: Kelvin probe force microscopy and conductive atomic force microscopy studies.

Nanoarchitecture by atomic manipulation is considered to be one of the emerging trends in advanced functional materials. It has a gamut of applications to offer in nanoelectronics, chemical sensing, and nanobiological science. In particular, highly ordered one-dimensional semiconductor nanostructures fabricated by self-organization methods are in high demand for their high aspect ratios and large number of applications.

The use of mosquito repellents at three sites in India with declining malaria transmission: surveys in the community and clinic.

Background: Repellents such as coils, vaporizers, mats and creams can be used to reduce the risk of malaria and other infectious diseases. Although evidence for their effectiveness is limited, they are advertised as providing an additional approach to mosquito control in combination with other strategies, e.g.

Laryngocele - a case report and review of literature.

This is case report of 35-year old male patient presented with hoarseness and swelling on left side of neck. The swelling was noticed by the patient for 8 months. It has been diagnosed clinically and radiologically as a combined laryngocele.