Serum angiotensin converting enzyme activity in patients with psoriasis.

Serum angiotensin converting enzyme activity is frequently increased in patients with active sarcoidosis. In spite of a reported association between sarcoidosis and psoriasis, serum angiotensin converting enzyme activities have not been reported for patients with psoriasis. We found the mean (SD) angiotensin-converting enzyme activity for 51 healthy subjects was 18.

Scintigraphic dissociation of reticuloendothelial and hepatocyte function in chronic vitamin A hepatotoxicity.

A discordant hepatic uptake between Tc-99m sulfur colloid and Ga-67 citrate has occurred in an adult patient with hepatotoxicity due to hypervitaminosis A. The authors believe this is a scintigraphic phenomenon related to the characteristics of the radiopharmaceuticals used and does not necessarily represent a true dissociation of various cellular functions of the liver.

An experimental endoscopic technique for reversing gastroesophageal reflux in dogs by injecting inert material in the distal esophagus.

After the lower esophageal sphincters of large mongrel dogs had been made surgically incompetent, the degree of sphincter incompetency was determined by the grade of esophagitis present and the reflux volume. Five dogs were endoscopically injected in the distal esophagus with 5 to 30 ml of Teflon paste during four to six injection sessions, and all five dogs developed transient increases in the reflux volumes. Each of the five dogs sloughed a portion of injected Teflon during the 4-month study.

Echocardiographic detection of ischemic and infarcted myocardium.

The purpose of this study was to determine the potential of a clinically adaptable two-dimensional echocardiographic system using computer enhancement and a mathematically defined integrated backscatter ratio for the early detection of ischemic and infarcted myocardium. Fifteen dogs had two-dimensional echocardiograms recorded during either open chest coronary occlusion (n = 5), closed chest occlusion (n = 5), occlusion followed by reperfusion (n = 3) or sham coronary occlusion (n = 2). A serial increase in integrated backscatter ratio, representing differences in returned ultrasound intensities between a reference point and specific myocardial regions, was detected between 7 and 12 minutes of complete occlusion in 9 of 12 animals (p less than 0.

Delayed hypersensitivity to mumps antigen in humans.

Sixty-one subjects, preselected for mumps sensitivity, were entered into a double-blind protocol to standardize Mumps Skin Test Antigen. Four lots of mumps antigen selected on the basis of in vitro potency tests were used. Four other antigens, Histoplasmin, Dermatophytin-O, Dermatophytin, and fluid tetanus toxoid were also tested; positive reactions for these four antigens occurred in 48, 68, 25, and 43% of individuals, respectively.

Bowenoid dysplasia of the vulva.

The histologic findings of five patients with clinically typical Bowenoid dysplasia (BD) allowed the authors to classify the vulvar and perineal biopsies of 18 patients under 40 years as BD and the vulvar biopsies of six patients under 40 years as squamous cell carcinoma in situ (CIS). The two best criteria for BD are cellular uniformity and absence of pilosebaceous involvement. Vesicular chromatin is a less constant feature of BD.

Scintigraphic evaluation of diabetic osteomyelitis: concise communication.

We have reviewed the three-phase bone scans, radiographs, and histologic findings of 39 diabetic patients with serious foot problems. The sensitivity and specificity of bone scans were 83% and 75%, respectively, for osteomyelitis of the small bones of the foot. The positive and negative predictive values were 87% and 69%, respectively.

A preliminary analysis of the ultrasound imaging characteristics of malignant breast masses as compared with x-ray mammographic appearances and the gross and microscopic pathology.

Thirty correctly diagnosed carcinomas were chosen for retrospective analysis of their ultrasound and X-ray imaging characteristics, and correlated with pathologic examination. It was determined that the ultrasound image correlated will with that revealed by radiographic techniques. The posterior attenuation shadow and the jagged wall were the prime indicators of malignancy in this study, occurring in 90 and 87% of the cases, respectively.

Glycogen-rich clear cell carcinoma of the breast: a light and electron microscopic study.

A glycogen-rich clear cell carcinoma arose in the breast of a 49-year-old woman. Light microscopic examination of the neoplasm revealed both intraductal papillary growth and stromal invasion. Electron microscopic examination demonstrated neoplastic cells that contained massive quantities of nonmembrane-bound particulate glycogen and that formed numerous acini.

Endobronchial granular cell tumor. Cytology of a new case and review of the literature.

We report the 45th case of endobronchial granular cell tumor in the literature and describe in detail the cytologic findings in bronchial brushings and post-brush washings. Our findings differ from those of the only other cytologic report of such a lesion. We review the literature and summarize the clinical and pathologic findings of endobronchial granular cell tumors.

Fatal benign phenytoin lymphadenopathy.

A 71-year-old man had status epilepticus and was treated with phenytoin (Dilantin) sodium. Subsequently, an absolute eosinophilia developed, which increased and reached its zenith immediately before the patient died. At autopsy, anasarca and an interstitial nephritis characterized predominantly by eosinophils and occasional focal necrotizing arteriolar glomerular lesions were found.

Primary intracranial endodermal sinus tumor. Case report.

Endodermal sinus tumor (yolk sac carcinoma), a germinal neoplasm, is rarely primary in the cranial cavity. The authors add a third case with the tumor located in the anterior third ventricular (suprasellar) region to the literature. Seventeen previously reported intracranial cases, mostly in the pineal region, are briefly reviewed.