A gene for all seasons: The evolutionary consequences of HIF-1 in carcinogenesis, tumor growth and metastasis.

Oxygen played a pivotal role in the evolution of multicellularity during the Cambrian Explosion. Not surprisingly, responses to fluctuating oxygen concentrations are integral to the evolution of cancer-a disease characterized by the breakdown of multicellularity. Poorly organized tumor vasculature results in chaotic patterns of blood flow characterized by large spatial and temporal variations in intra-tumoral oxygen concentrations.

Comparative study between charge and spin thermoelectric figure of merits in an antiferromagnetic ring.

Considering the unique and diverse characteristic features of antiferromagnetic (AFM) systems, here in our work, we explore spin-dependent thermoelectric behavior in an AFM ring geometry. A reasonably large (≫1) spin figure of merit, referred to as, is obtained under suitable input conditions. Two important prerequisites are (i) breaking the symmetry among up and down spin sub-Hamiltonians and (ii) generating different asymmetric transmission line shapes across a Fermi energy for two opposite spin electrons.

Role of inter-electrode coupling on thermoelectricity in an interferometric geometry: a new proposition.

Efficient thermoelectric (TE) energy conversion is one of the most desirable solutions of our current day energy crisis. Exploiting the effect of quantum interference among electronic waves, in this work we propose a prescription of getting high TE efficiency, the so-called(), considering an interferometric geometry where a loop conductor is clamped between two heat baths. Unlike conventional junction configurations, we introduce an additional path for electron transfer directly from source to drain, due to their close proximity.

Digest: Natural selection fluctuates at an extremely fine spatial scale inside a wild population of snapdragon plants.

Marrot et al. used snapdragon plants on a small island to experimentally investigate how spatial structure influences the evolution of biological communities. Using a spline-based fitness function, they studied the varying relationships between traits under selection and driving environmental factors in snapdragons.

Senescence-Induced Chemoresistance in Triple Negative Breast Cancer and Evolution-Based Treatment Strategies.

Triple negative breast cancer (TNBC) is classically treated with combination chemotherapies. Although, initially responsive to chemotherapies, TNBC patients frequently develop drug-resistant, metastatic disease. Chemotherapy resistance can develop through many mechanisms, including induction of a transient growth-arrested state, known as the therapy-induced senescence (TIS).