Publications by authors named "Ranieli Guizzo"
Aim: To evaluate the effects of chronic exposure to ethanol in the liver and the expression of inflammatory genes in zebrafish.
Methods: Zebrafish ( = 104), wild type, adult, male and female, were divided into two groups: Control and ethanol (0.05 v/v).
Article Synopsis
- Ethanol is shown to affect the central nervous system in zebrafish, leading to behavioral changes such as increased disinhibition and reduced anxiety when exposed to it.
- The study investigated the impact of the probiotic Lactobacillus rhamnosus GG (LGG) on adult zebrafish exposed to ethanol, comparing groups that received different combinations of LGG and ethanol.
- Findings reveal that while ethanol exposure reduced anxiety levels in zebrafish, LGG did not have a significant effect on their behavior, differing from results seen in other animal studies.
Zebrafish is a powerful tool in pharmacological research and useful to identify new therapies. Probiotics can offer therapeutic options in alcoholic liver disease. This study was done in two independent experiments: first, we confirmed the intestinal colonization of probiotic Lactobacillus rhamnosus GG (LGG) after ethanol exposure.
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