Publications by authors named "Rania M Kamel"
Article Synopsis
- The kidneys are crucial for producing tyrosine (Tyr) from phenylalanine (Phe), but in chronic kidney disease (CKD), this process is impaired, leading to lower Tyr/Phe ratios in patients.
- A new, cost-effective High-Performance Thin-Layer Chromatography (HPTLC) method was developed to measure Tyr and Phe levels in serum using a specific mobile phase and denser scanning techniques.
- The method's effectiveness was validated for selectivity, linearity, precision, and accuracy, showing high separation efficiency and eco-friendliness, and successfully applied to human serum samples.
In recent years, there has been considerable interest in using amino acids like tryptophan (Trp) and tyrosine (Tyr) as biomarkers for various diseases, including type 2 diabetes mellitus (T2D). In diseases like T2D, the metabolism of Trp and Tyr is altered. The activity of enzymes involved in Trp metabolism increases, leading to a decrease in its serum level.
View Article and Find Full Text PDFLiquid biopsy analysis represents a suitable alternative analysis procedure in several cases where no tumor tissue is available or in poor patient conditions. Amino acids can play a crucial role in aiding cancer diagnosis. Monitoring of tryptophan (Trp) catabolism can aid in tracking cancer progression.
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