Emerging insights into the role of natural products and miRNAs in psoriasis: from pathophysiology to precision medicine.

Psoriasis is a sustainable skin disease characterized by inflammation resulting from the interaction between immune cells and keratinocytes. Significant advancements have been achieved in studying the molecular process behind noncoding and coding genes, leading to valuable insights for clinical therapy. Nevertheless, our comprehension of this intricate ailment remains ambiguous.

Mammary fat globules as a source of mRNA to model alterations in the expression of some milk component genes during lactation in bovines.

Background: The milk's nutritional value is determined by its constituents, including fat, protein, carbohydrates, and minerals. The mammary gland's ability to produce milk is controlled by a complex network of genes. Thereby, the fat, protein, and lactose synthesis must be boost in milk to increase milk production efficiency.

An Exploration of Lived Experiences of Sexually and Gender Diverse Staff Members in Higher Education: A Case Study.

Sexually and gender diverse staff in Higher Education Institutions may experience a sense of belonging and acceptance in inclusive environments, but may also face discrimination and bias, leading to feelings of isolation and exclusion. This paper reports on findings from 40 in-depth interviews and six focus group discussions with LGBTQIA+ self-identified staff members in a HEI and LGBTQIA+ allies who may identify as LGBTQIA+ themselves. Findings reveal that first impressions when joining a university as a staff member may have a long-lasting effect, while both positive and negative experiences are present.

miRNAs dysregulation in ankylosing spondylitis: A review of implications for disease mechanisms, and diagnostic markers.

Epigenetic processes, including non-coding RNA, histone modifications, and DNA methylation, play a vital role in connecting the environment to the development of a disorder, especially when there is a favorable genetic background. Ankylosing Spondylitis (AS) is a chronic type of spinal arthritis that highlights the significance of epigenetics in diseases related to autoimmunity and inflammation. MicroRNAs (miRNAs) are small non-coding RNAs that are involved in both normal and aberrant pathological and physiological gene expression.

Predicting the Consistency of Pituitary Macroadenomas: The Utility of Diffusion-Weighted Imaging and Apparent Diffusion Coefficient Measurements for Surgical Planning.

Understanding the consistency of pituitary macroadenomas is crucial for neurosurgeons planning surgery. This retrospective study aimed to evaluate the utility of diffusion-weighted imaging (DWI) and the apparent diffusion coefficient (ADC) as non-invasive imaging modalities for predicting the consistency of pituitary macroadenomas. This could contribute to appropriate surgical planning and therefore reduce the likelihood of incomplete resections.

The prognostic value of bone marrow retention index and bone marrow-to-liver ratio of baseline 18F-FDG PET/CT in diffuse large B-cell lymphoma.

Objective: To determine prognostic value of bone marrow retention index (RI-bm) and bone marrow-to-liver ratio (BLR) measured on baseline dual-phase F-FDG PET/CT in a series of newly diagnosed patients with diffuse large B-cell lymphoma (DLBCL) treated homogeneously with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy.

Patients And Methods: This prospective study enrolled 135 patients with newly diagnosed DLBCL. All patients underwent dual-phase F-FDG PET/CT.

Eichhornia crassipes from wastes to valuable products in water purification and influence on growth and impregnability in overwhelmed broiler chickens.

Background: The implementation of green technologies is continually gaining attention worldwide and was considered for removing water pollutants and treating municipal water before its disposal.

Aim: Evaluation of the laboratory antimicrobial actions and chelating activities, and the field influence of on performance, biochemical and immunoglobulin concentrations, and intestinal microbiota in overwhelmed broiler chickens.

Methods: We assessed the laboratory antimicrobial actions of 1% suspension against bacterial ( O157: H7 and Typhimurium) and fungal ( and ) microorganisms using a 96-well minimal inhibitory concentration, and the chelating activities of against calcium sulfate and copper sulfate.

The Impact of Adding Digital Breast Tomosynthesis to BI-RADS Categorization of Mammographically Equivocal Breast Lesions.

Digital mammography (DM) is the cornerstone of breast cancer detection. Digital breast tomosynthesis (DBT) is an advanced imaging technique used for diagnosing and screening breast lesions, particularly in dense breasts. This study aimed to evaluate the impact of combining DBT with DM on the BI-RADS categorization of equivocal breast lesions.

Magnetic Resonance Imaging Features of Rhino-Orbito-Cerebral Mucormycosis in Post-COVID-19 Patients: Radio-Pathological Correlation.

There has been a notable increase in rhino-orbito-cerebral mucormycosis (ROCM) post-coronavirus disease 2019 (COVID-19), which is an invasive fungal infection with a fatal outcome. Magnetic resonance imaging (MRI) is a valuable tool for early diagnosis of ROCM and assists in the proper management of these cases. This study aimed to describe the characteristic MRI findings of ROCM in post-COVID-19 patients to help in the early diagnosis and management of these patients.

Disordered Eating Behaviors and Insulin Restriction in Saudi Adolescents and Young Adults with Type 1 Diabetes.

The prevalence of disordered eating behaviors (DEBs) in type 1 diabetes (T1D) has been studied globally; however, data from Saudi Arabia and Arab-speaking countries are scarce. This study aimed to measure the prevalence of DEBs and associated clinical characteristics in adolescents and young adults with T1D, and the impact of DEBs on glycemic parameters. A total of 265 adolescents and young adults with T1D (aged 12-25 years) were recruited randomly from the registry at the Jazan Endocrinology and Diabetes Center, Saudi Arabia.

Antibiotics use and its association with Multi-Drug Resistance in a Tertiary Care Geriatrics Hospital in Egypt.

Introduction: Multi-Drug Resistance (MDR) is common in hospitalized geriatric patients. The study aims to investigate the pattern of antibiotic use and determine its association with MDR in hospitalized geriatric patients.

Methodology: A retrospective cohort study including 193 geriatric patients admitted to a Geriatric Intensive Care Unit (GICU) in a tertiary care Geriatrics hospital in Egypt, throughout a consecutive 6 months duration.

Nile tilapia bones as eco-friendly alternative in water treatment and enhancing performance and immunity in broiler chickens.

Background: Water pollution has become a major threat to the environment and the living so an eco-friendly bio-filter was chosen for its merits over conventional techniques.

Aim: Investigating the purifying activities of the Tilapia bone powder against inorganics, heavy metals, and microbial water pollutants and its impacts on performance, biochemical and antioxidant levels, cortisol and immunoglobulin concentrations, and intestinal microbiota in challenged broiler chickens.

Methods: The activity of Tilapia bone powder was evaluated against magnesium chloride and lead nitrate using tube minimal inhibitory concentration (MIC), as well as against O1527:H7, , , , , and using a 96-micro-well MIC.

Skin colonization of Staphylococcus aureus harboring superantigen toxin genes and its correlation with serum IL-22 level in psoriasis patients.

Psoriasis is a chronic debilitating skin disease with an estimated prevalence reaching 2% of the worldwide population. Psoriatic disease is driven by the interactions among innate and adaptive immune systems with structural components of the skin. Interleukin (IL)-22 mediates keratinocyte proliferation and epidermal hyperplasia, and changes in the structure of skin flora can play a role in the secretion of IL-22.

The efficiency of natural-ecofriendly clay filters on water purification for improving performance and immunity in broiler chickens.

Background: Innovative water treatments and purification processes have become a point of interest to provide solutions and meet the basic water requirements and demands. Clay plays a key role in environmental protection from pollutants through ion exchange and/or adsorption.

Aim: The study evaluated the adsorption and antimicrobial efficiency of clay in purifying polluted water, as well as the influence of clay-purified water on performance, immunity, and microbial counts.

Synoptic Overview of Exotic , and (Caesalpinioideae, Mimosoid Clade, Fabaceae) in Egypt.

For the first time, an updated checklist of , and species in Egypt is provided, focusing on the exotic species. Taking into consideration the retypification of genus ratified at the Melbourne International Botanical Congress (IBC, 2011), a process of reclassification has taken place worldwide in recent years. The review of and its segregates in Egypt became necessary in light of the available information cited in classical works during the last century.

Efficacy of Dexmedetomidine Infusion Without Loading Dose on Hemodynamic Variables and Recovery Time During Craniotomy: A Randomized Double-blinded Controlled Study.

Background: Maintaining hemodynamic stability during intracranial surgery is one of the most important tasks. There is no general agreement regarding which anesthetics are optimal for craniotomy. Propofol and short-acting opioids are usually used, but their use is not without side effects.

Moderations in performance, immunity, tissue architecture, and vaccine viability induced by water magnetization in broiler farms.

Background And Aim: Water magnetization contributes to increased molecular ionization and fluidity, which improves biological activities. This study tests the influence of magnetic water on the viability of the Newcastle vaccine and the survival of and Typhimurium, as well as the influence of magnetic water in face of water impurities' challenges on performance, immunity, and tissue architecture in broiler chickens.

Materials And Methods: An 96-micro-well plate minimal inhibitory concentration was utilized to test the influence of water, saline, and magnetic water on Newcastle vaccine viability and O157:H7 and .

Examining Heterogeneity of Food Fortification and Biofortification Business Models: Emerging Evidence for a Typology.

Efforts to address Micronutrient deficiencies (MNDs) in lower-and middle-income countries (LMICs) have been gaining pace in recent years. Commodities such as staple foods (e.g.

Case Report: Prolonged Viral Shedding in Six COVID-19 Patients.

COVID-19 has surfaced as a multi-organ disease predominantly affecting the respiratory system. Detection of the viral RNA through reverse transcriptase-PCR (RT-PCR) from a nasopharyngeal or throat sample is the preferred method of diagnosis. Recent evidence has suggested that COVID-19 patients can shed the SARS-CoV-2 for several weeks.

An overview of healthcare-associated infections in a tertiary care hospital in Egypt.

Background: Healthcare-associated infection (HAI) is a major problem in healthcare facilities and is associated with increased morbidity and mortality and prolonged hospital stay. This study aims to determine the incidence rate, risk factors, and bacterial aetiology of HAI in a tertiary care hospital in Mansoura, Egypt.

Methods: This is a prospective observational study carried out over 12 months in different departments of Mansoura New General Hospital (MNGH).

Impact of lighting color and duration on productive performance and Newcastle disease vaccination efficiency in broiler chickens.

Background And Aim: Manipulating lighting colors and regimens is considered an effective mean for improving broiler productivity. The influence of red, blue, and white light-emitting diode (LED) was investigated using three different regimens of lighting and darkness; continuous 23 h light (L):1 h dark (D), continuous 18 h L:6 h D, and intermittent 16 h L:8 h D hours on the performance, carcass weight (CW), feed and water intake (WI), serum glucose (GLUCO), triglycerides (TG), and cholesterol (TC), intestinal bacterial load, growth and metabolic hormones, and efficiency of Newcastle disease (ND) vaccine.

Materials And Methods: A total of 252 1-day-old Ross broilers on deep litter were divided into nine groups.

Does light intensity affect the behavior, welfare, performance, meat quality, amino acid profile, and egg quality of Japanese quails?

The current study aimed to explore the impact of different light intensities on behavior, welfare, performance, meat quality, amino acid content, and egg quality of Japanese quails. A total of 600 1-day-old Japanese quail chicks were used (300/batch). Chicks were homogeneously classified into 3 groups (each of 100); low (10 lux), moderate (50 lux).

Improving hepatic mitochondrial biogenesis as a postulated mechanism for the antidiabetic effect of Spirulina platensis in comparison with metformin.

Various nutritional and medicinal potencies have been accredited to metabolites from the cyanobacteria, Spirulina platensis (Arthrospira platensis) sp. Hence, our study was designed to examine whether the Spirulina supplementation would possess beneficial effects in type 2 diabetes mellitus (T2DM) in comparison with metformin. High-fat diet/low-dose streptozotocin (HFD/STZ) model was adopted and the diabetic rats were orally treated with metformin (200 mg/kg) or Spirulina (250 or 500 or 750 mg/kg) for 30 days.

Influence of microclimatic ammonia levels on productive performance of different broilers' breeds estimated with univariate and multivariate approaches.

Background And Aim: Birds litter contains unutilized nitrogen in the form of uric acid that is converted into ammonia; a fact that does not only affect poultry performance but also has a negative effect on people's health around the farm and contributes in the environmental degradation. The influence of microclimatic ammonia emissions on Ross and Hubbard broilers reared in different housing systems at two consecutive seasons (fall and winter) was evaluated using a discriminant function analysis to differentiate between Ross and Hubbard breeds.

Materials And Methods: A total number of 400 air samples were collected and analyzed for ammonia levels during the experimental period.

Team Approach Helps Patient Survive High-voltage Electric Burn.

A 20-year-old man was subjected to high-voltage electric burn, which was occupational. The patient was admitted to AlGalaa Military Medical Complex almost 2 weeks after the accident had happened. According to Lund and Browder's chart, the patient had a 40% total body surface area burn involving the upper limbs, anterior and posterior trunks, and the left thigh (third- and fourth-degree burns).