Publications by authors named "Rania A El Gedaily"

Ethnopharmacological Relevance: Scientific publications documented the use of plants from Genus Malva to treat inflammatory diseases and skin disorders by our ancestors. Malva parviflora L. has reported benefits for wound healing in traditional medicine; however, there is a lack of experimental study to validate these claims.

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Roxb. Sweet is a shrub known for its richness in secondary metabolites. A callus culture protocol was established to enhance its chemical profile.

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Jatropha variegata and Jatropha spinosa (family: Euphorbiaceae) are utilized in Yemeni traditional medicine to treat respiratory tract infection and in different skin conditions such as wound healing, as antibacterial and hemostatic. In this study, we evaluated the cytotoxicity and the antiviral activities of the methanolic J. variegata (leaves: Ext-1, stems: Ext-2, and roots: Ext-3), and J.

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(Roxb.) Sweet is one of the well-known traditionally-used Indian plants. This plant is rich in secondary metabolites like phenolic acids, flavonoids, alkaloids, glycosides, saponins, and carbohydrates.

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Background: Breast cancer is a prevalent malignant tumor that affects women worldwide. The primary challenge in treating breast cancer is combating drug resistance, which contributes to relapse and metastasis. Jatrophone is a unique macrocyclic jatrophane diterpene found in various Jatropha and Euphorbia species.

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Article Synopsis
  • Plant secondary metabolites are important for developing new and safe drugs, and this study focuses on using ethanolic extract from Roxb. Sweet to create eco-friendly zinc oxide nanoparticles (ZnO NPs) with a small average size of 6.80 nm.
  • Various phenolic compounds were identified in the extract, with chlorogenic acid being the most abundant at 1803.84 μg/g.
  • The study found that ZnO NPs have a stronger antiviral effect against coronavirus 229E than the extract alone, and their combination shows the best results, indicating potential for future biomedical applications.
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is native to South America and is cultivated worldwide mostly for its medicinal benefits. The plant is used traditionally in respiratory disorders such as dry cough, in the treatment of fever and stomach pain, and as an antimicrobial and analgesic. The antisickling and antioxidant effects of the flowers of (Kunth) Dugand (red) and cultivar alba (white) were compared using an assay in 2% sodium metabisulfite sickling induction model, DPPH, and metal chelation assays.

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Plant resins are rich in bioactive compounds with high medicinal values. However, the chemistry and anti-inflammatory activity of the resins produced by trees of the genus Eucalyptus were scarcely investigated. The inflammatory targets cyclooxygenase-1 (COX-1), COX-2, TNF-, NF-B, and NO were significantly inhibited by the methanolic extract of Eucalyptus maculata kino resin (EME) and its CHCl soluble fraction (MCF).

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(Cav.) DC (Malpighiaceae) is one of the well-known traditionally used remedies worldwide. This study aims to explore the leaves' metabolome via Quadrupole-Time-of-Flight-Liquid-Chromatography-Mass Spectrometry and to investigate the neuroprotective effect of leaves using lipopolysaccharide (LPS) induced Alzheimer's disease model.

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Article Synopsis
  • The study investigated the antibacterial properties of Lam. stem bark, traditionally used in Africa for ailments like gastritis and wound infections.
  • Four compounds were identified, with methyl rosmarinate showing significant activity against methicillin-resistant Staphylococcus aureus (MRSA) and other pathogens.
  • The research suggests that the identified compounds could be effective in a dual-target approach for antibacterial treatment against MRSA.
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Although Malpighia glabra Linn. fruits are well studied for their nutritional and medicinal prominence; little attention has been given to the leaves. Our study intends to investigate the leaves metabolic profile using Q-TOF LC/MS/MS (Quadrupole-Time-of-Flight-Liquid-Chromatography-Mass-Spectrometry), and to explore their in vivo hepatoprotective activity in rats using CCL -induced hepatic damage model and silymarin as standard.

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Eucalyptus barks contain complex biomass of constituents with considerable chemical and structural diversity. Reports about Eucalyptus sideroxylon Cunn. ex Woolls bark composition and biological activities are limited.

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Sugarcane ( L.) is an important perennial grass in the Poaceae family cultivated worldwide due to its economical and medicinal value. In this study, a combined approach using mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy was employed for the large-scale metabolite profiling of sugarcane juice and its by-product molasses.

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Eucalyptus is one of the most important and highly exploited genus in family Myrtaceae. An UPLC/PDA/ESI-qTOF-MS method was adopted to identify Eucalyptus sideroxylon Cunn. ex Woolls leaves phytoconstituents.

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