Publications by authors named "Rani T"

Objective: Hemodialysis patients with chronic kidney disease often exhibit inflammation characterized by elevated levels of C-reactive protein, Interleukin 6 and tumor necrosis factor-alpha, and they are shown to be associated with cardiovascular impairment and enhanced renal failure. This study aims to assess the impact of fish oil intake on inflammation indicators in adult hemodialysis patients.

Methods: From the inception to December 2023, the datasets Cochrane Central, Google Scholar, Science Direct, Embase, and Pubmed were examined.

View Article and Find Full Text PDF

The current study aimed to evaluate the bioequivalence of a new generic combination of simvastatin and ezetimibe with the reference formulation. An open-label, randomized, 3-period, 3-sequence, crossover study, including 60 healthy volunteers, was implemented. Participants received the test and reference formulation, each containing 20 mg of simvastatin and 10 mg of ezetimibe as a single-dose tablet, separated by a minimum of 2-week washout periods.

View Article and Find Full Text PDF

The present study aimed to assess the bioequivalence of a new apixaban generic with reference formulation. Twenty-six healthy volunteers were recruited for an open-label, balanced, randomized, 2-treatment, 2-sequence, 2-period, single oral dose study. Following overnight fasting, each volunteer received 5 mg of apixaban test and reference formulations as single doses, separated by a 1-week washout period.

View Article and Find Full Text PDF

The demand for an effective system that combines cutting-edge technologies with medical research to improve healthcare systems has increased with the development of medical technology. The most fundamental form of disease prevention is taking the right medication when needed. With the right care, many fatal diseases can be cured or prevented.

View Article and Find Full Text PDF
Article Synopsis
  • - The ideal method for diagnosing acute chest pain is controversial, especially with the increasing use of coronary computed tomography angiography (CTA) and the declining popularity of functional tests like stress echocardiography (SE).
  • - While coronary CTA has many benefits, it also has limitations, necessitating a clear understanding of when SE should be used and which patients require diagnostic testing.
  • - This review article examines the role of SE, relevant guidelines, and compares the effectiveness of SE versus CTA, while also discussing new factors that could enhance SE in the context of evolving cardiovascular diagnostics.
View Article and Find Full Text PDF

Chronic Otitis Media-Squamosal type is an erosive process, which when confined to ossicular chain causes varying degrees of hearing impairment. As the disease progresses to involve surrounding vital structures, it causes various complications like facial palsy, vertigo, mastoid abscess, which are more common than the other intracranial complications, and require a definitive surgical intervention i.e.

View Article and Find Full Text PDF

A slotted plus-shaped patch antenna (PSPA) with defected ground structure (DGS) is modelled and proposed for 5G GHz and WiMAX applications by using computer simulation technology (CST) MWS suite. The PSPA incorporates a rectangular slotted plus-shaped metal patch and a DGS. The .

View Article and Find Full Text PDF
Article Synopsis
  • A sixteen-element dual band microstrip array antenna has been developed, comprising eight circular and eight rectangular patch elements suitable for various wireless applications like ISM, Bluetooth, Zigbee, WiMAX, and WiFi at 2.4/5/6 GHz.
  • The antenna functions in dual bands of 2.20-3.18 GHz and 4.81-7.21 GHz, demonstrating effective performance characterized by low return loss, high gain, and directivity across these frequencies.
  • Performance validation was conducted using three professional simulators (HFSS, FEKO, CST) to ensure the antenna meets desired specifications for multi-application use in everyday technology.
View Article and Find Full Text PDF

In this research work, a π-shaped slotted microstrip patch antenna (MPA) with a partial ground structure for lower fifth generation (5G)/wireless fidelity (WiFi)/worldwide interoperability for microwave access (WiMAX) applications is presented. The proposed MPA is optimized and designed by using the computer simulation technology (CST) microwave studio (MWS) suite version of 2018. The π-shaped slotted MPA is mounted on low loss dielectric material Rogers RT5880 with a height of 0.

View Article and Find Full Text PDF

Financial development is a multidimensional process that contributes to economic growth but sometimes it has a devastating effect on climate change. No country can achieve sustainable development goals without caring the environmental quality. The present study investigates the moderating role of globalization (KOF) in determining the financial development (FD) on environmental degradation in the SAARC countries from 1990 to 2020.

View Article and Find Full Text PDF

Indiscriminate, unhygienic and unscientific disposal of solid wastes poses significant risks leading to soil, water and air pollution. Abiotic and nonenzymatic rapid thermochemical processing technology provides a solution for the management of degradable solid waste at the source, converting it to organic digestate fertiliser within a day, thus overcoming the main drawback of the long time span required for composting. A study was performed to evaluate the maturity parameters and the extent of humification of the thermochemical digestate fertiliser and the raw biowaste substrate.

View Article and Find Full Text PDF

It is a global challenge to achieve sustainable economic growth by improving the environment. The present study discussed the role of the financial development sector in achieving sustainable economic growth and environmental quality in South Asian countries from 1990 to 2020 by controlling labour force participation, globalization, industrialization, and the education sector. A feasible generalized least squares (FGLS) panel data econometric technique has been used to check the relationship among the variables.

View Article and Find Full Text PDF

Ketamine is a dissociative anesthetic commonly used for the induction and maintenance of anesthesia and has a well-known role in analgesia. However, it also has the potential for addiction, which can lead to neurological, psychological, systemic, and biochemical consequences. In this case report, we are highlighting a rare case of a young Asian female with Ketamine addiction who presented with urinary complaints.

View Article and Find Full Text PDF
Article Synopsis
  • Depression is a widespread mental health disorder characterized by symptoms like persistent sadness, loss of interest, increased anxiety, sleep disturbances, and cognitive issues, but its exact causes are still unclear.
  • Research indicates that inflammatory cytokines, especially tumor necrosis factor-alpha (TNF-α) and interleukins (ILs), may play significant roles in both the development and treatment of depression, with elevated levels found in depressed patients.
  • TNF-α inhibitors, such as etanercept and infliximab, are being studied as promising new treatments for depression, with evidence from animal models and clinical studies showing they can reduce depressive symptoms and improve mood.
View Article and Find Full Text PDF

Aim And Objective: This study was carried out to comparatively assess the efficiency of four methods of obturation viz Lentulo spiral, Navi tip syringe, Bi directional spiral, and Past inject carrier in deciduous teeth using vista scan.

Materials And Methods: A total sample of 100 primary root canals [4 groups of 25 canals each] with 2/3 of root length were selected and randomly allocated into four different obturating techniques, i.e.

View Article and Find Full Text PDF
Article Synopsis
  • Anti-tuberculosis drugs like Isoniazid and Rifampicin can cause liver damage (hepatotoxicity) in rats, leading to elevated liver enzymes and bilirubin levels.
  • A study tested the liver-protective effects of Solanum lycopersicum (tomato extract) on rats given these drugs, comparing it to a known liver protector, silymarin.
  • The results showed that the 80 mg/kg dose of Solanum lycopersicum significantly reduced liver enzyme levels and increased albumin, suggesting it is effective in treating drug-induced liver damage.
View Article and Find Full Text PDF

Chitosan and its derivatives have numerous applications in wastewater treatment as bio-coagulants, flocculants and bio-adsorbents against both particulate and dissolved pollutants. Chitinolytic bacteria secrete an array of enzymes, which play crucial role in chitin to chitosan conversion. Consequently, there is a growing demand for identification and characterization of novel bacterial isolates with potential implications in chitosan production.

View Article and Find Full Text PDF

Enzymatic deconstruction of chitin to chitobiose is of significant interest in view of its various biological applications. Here we report detailed insights into the chitin degradation by chitinase-E from a chitinolytic bacterium Chitiniphilus shinanonensis (CsChiE). CsChiE was optimally active at 50 °C in 50 mM sodium phosphate pH-7.

View Article and Find Full Text PDF

Plant growth promoting rhizobacteria (PGPR) promote plant growth and activate defense response against phytopathogens. At the subcellular level plant-PGPR interaction is less understood, which would be essential for future improvement(s) of PGPR formulations. In a rigorous screening process, that also involved efficient PGPR strains, Bacillus sonorensis RS4 was selected to study partner-triggered interactions.

View Article and Find Full Text PDF

Plants being sessile are under constant threat of multiple abiotic and biotic stresses within its natural habitat. A combined stress involving an abiotic and a biotic factor reportedly increases susceptibility of the plants to pathogens. The emerging threat, collar rot disease of chickpea (caused by Sacc.

View Article and Find Full Text PDF

Harpin, an elicitor from Pseudomonas syringae pv. syringae, induces systemic acquired resistance in non-host plants, providing resistance to phytopathogens. Poor assimilation of harpin is a major constraint in foliar application as biopesticide.

View Article and Find Full Text PDF

Understanding features that determine transglycosylation (TG) activity in glycoside hydrolases is important because it would allow the construction of enzymes that can catalyze controlled synthesis of oligosaccharides. To increase TG activity in two family 18 chitinases, chitinase D from Serratia proteamaculans ( SpChiD) and chitinase A from Serratia marcescens ( SmChiA), we have mutated residues important for stabilizing the reaction intermediate and substrate binding in both donor and acceptor sites. To help mutant design, the crystal structure of the inactive SpChiD-E153Q mutant in complex with chitobiose was determined.

View Article and Find Full Text PDF

Simple sequence repeats (SSRs), simple tandem repeats (STRs) or microsatellites are short tandem repeats of 1-6 nucleotide motifs. They are twice as abundant as the protein coding DNA in the human genome and yet little is known about their functional relevance. Analysis of genomes across various taxa show that despite the instability associated with longer stretches of repeats, few SSRs with specific longer repeat lengths are enriched in the genomes indicating a positive selection.

View Article and Find Full Text PDF