WFS1 Gene-associated Diabetes Phenotypes and Identification of a Founder Mutation in Southern India.

Context: Wolfram syndrome (WFS) is a rare autosomal recessive disorder characterized by juvenile-onset diabetes, diabetes insipidus, optic atrophy, deafness, and progressive neurodegeneration. However, due to the progressive nature of the disease and a lack of complete clinical manifestations, a confirmed diagnosis of WFS at the time of onset of diabetes is a challenge.

Objective: With WFS1 rare heterozygous variants reported in diabetes, there is a need for comprehensive genetic screening strategies for the early diagnosis of WFS and delineating the phenotypic spectrum associated with the WFS1 gene variants in young-onset diabetes.

Hydrothermal liquefaction of Nostoc ellipsosporum biomass grown in municipal wastewater under optimized conditions for bio-oil production.

Microalgae offer numerous potential applications, however the industrial scale-up of algal technology still remains a challenge due to high production cost. Optimization of growth conditions and integration with waste streams can improve the economic viability of microalgal production systems. This study investigated on the optimal growth conditions of microalgae Nostoc ellipsosporum cultivated in municipal wastewater with the objective of achieving maximum biomass production, nutrient removal efficiency and bio-oil yield.

Anaerobic tapered fluidized bed reactor for starch wastewater treatment and modeling using multilayer perceptron neural network.

Anaerobic treatability of synthetic sago wastewater was investigated in a laboratory anaerobic tapered fluidized bed reactor (ATFBR) with a mesoporous granular activated carbon (GAC) as a support material. The experimental protocol was defined to examine the effect of the maximum organic loading rate (OLR), hydraulic retention time (HRT), the efficiency of the reactor and to report on its steady-state performance. The reactor was subjected to a steady-state operation over a range of OLR up to 85.