Arterial repair after stenting and the effects of GM6001, a matrix metalloproteinase inhibitor.

Objectives: This study compared the extracellular matrix (ECM) and cellular responses after stenting to balloon angioplasty (BA) and to determine the late effects of matrix metalloproteinase (MMP) inhibition on arterial repair after stenting.

Background: Although stenting is the predominant form of coronary intervention, there is limited understanding of the early and late arterial response.

Methods: In a double-injury rabbit model, adjacent iliac arteries in 87 animals received BA (3.