Publications by authors named "Ranga Goud Rayapolu"
Pharm Dev Technol
June 2024
Article Synopsis
- Posaconazole (PCZ) is an antifungal medication limited by poor solubility, and this study aimed to enhance its oral bioavailability using nanocrystalline solid dispersion (NCS).
- The optimized NCS formulation, using specific surfactants and polymers, resulted in smaller, stable particles and significantly increased the saturation solubility of PCZ by 18 times compared to the standard drug.
- Pharmacokinetic studies in Wistar rats showed that the NCS formulation improved the concentration and area under the curve (AUC) of PCZ by approximately 2.6 times compared to existing products, indicating a successful method for enhancing its absorption.
