Apo-AII is an elevated biomarker of chronic non-human primate ethanol self-administration.

Aims: Serum protein profiles were examined in naïve, ethanol self-administering and ethanol abstinent cynomolgus monkeys (Macaca fasicularis) to search for differences in protein expression which could possibly serve as biomarkers of heavy ethanol consumption.

Methods: Surface-enhanced laser desorption ionization time-of-flight (SELDI-ToF) mass spectrometry was used for proteomic profiling of serum.

Results: Two proteins were identified by SELDI-ToF to be increased in ethanol self-administering compared with abstinent animals.