Publications by authors named "Randy J Epstein"
Article Synopsis
- The study evaluated the effects of "epi-on" corneal crosslinking on visual acuity in patients diagnosed with keratoconus through a multicenter trial with randomized treatment groups.
- About 2,228 subjects were treated, with significant visual acuity improvements noted at both 6 and 12 months post-treatment, specifically in corrected and uncorrected distance visual acuity, as well as corneal curvature.
- The procedure was well-tolerated, with only a small percentage (8.7%) experiencing mild adverse events, and no serious complications reported, indicating a strong safety and efficacy profile for the treatment.
Article Synopsis
- - The study aimed to evaluate changes in corneal thickness (pachymetry) after a new epithelium-on crosslinking (CXL) procedure called EpiSmart.
- - A total of 101 eyes were analyzed at multiple time points (baseline, 3, 6, and 12 months post-CXL), showing no significant changes in thickness with measurements remaining stable around 450 microns throughout the study.
- - The conclusion indicated that the EpiSmart CXL procedure did not result in significant corneal thinning over a year, as confirmed by the measurements taken.
A 41-year-old man presented 10 years after uneventful laser in situ keratomileusis (LASIK) with symptomatic post-LASIK ectasia. He had treatment with the classic Dresden epithelium-off technique and presented 4 years later with progression of the ectasia. He was subsequently retreated with conductive keratoplasty (CK) followed by a new proprietary epithelium-on corneal collagen crosslinking (CXL) procedure using a proprietary transepithelial riboflavin formulation and delivery system on the following day.
View Article and Find Full Text PDFPurpose: To report the postoperative clinical course of 3 patients who underwent corneal transplantation with corneal allografts contaminated with Clostridium perfringens and to evaluate the risk factors for anaerobic contamination in 2 donors.
Methods: Patient records and adverse reaction reports from a single eye bank related to cases of posttransplant C. perfringens endophthalmitis were reviewed.
Purpose: To evaluate the safety and effectiveness of the LipiFlow System compared to the iHeat Warm Compress (WC) for adults with meibomian gland dysfunction (MGD).
Methods: This was a non-significant risk, prospective, open-label, randomized, crossover multicenter clinical trial. One hundred thirty-nine subjects were randomized between LipiFlow (n=69) and WC control (n=70).
Purpose: to report the successful treatment of two patients who developed flap necrosis preceded by recurrent epithelial ingrowth and interface fluid syndrome after LASIK.
Methods: patient 1 was treated with epithelial debridement and flap suturing. Patient 2 was initially treated with epithelial debridement and flap suturing, but developed recurrent epithelial ingrowth in the right eye and 2 weeks later in the left eye.
Objective: To determine whether the duration of mitomycin C (MMC) 0.02% application affects visual outcome or the incidence of subepithelial haze in patients undergoing photorefractive keratectomy (PRK) with prophylactic administration of MMC.
Design: Retrospective, comparative case series.
Culture-positive endophthalmitis after implantation of intraocular Collamer lens.
J Cataract Refract Surg
October 2009
We report a case of culture-positive bacterial endophthalmitis following implantation of a Staar intraocular Collamer lens (ICL). The patient presented 4 days after uneventful sutureless surgery with decreased visual acuity, redness, and photosensitivity. Inflammation increased over the next 24 hours, which prompted a tap for culture and intravitreal injection of antibiotic agents.
View Article and Find Full Text PDFPurpose: To evaluate the potential effect of topical mitomycin C (MMC) on the corneal endothelium of myopic patients undergoing photorefractive keratectomy (PRK).
Methods: Sixteen eyes with a planned ablation depth >75 microm underwent PRK followed by 0.02% MMC applied for 12 seconds using a methylcellulose sponge.
Purpose: To describe a noninvasive technique that can be used to support a clinically suspected diagnosis of epithelial downgrowth in patients who have previously undergone penetrating keratoplasty (PK).
Methods: Previously resected corneal buttons of 14 patients who developed signs suggestive of epithelial downgrowth after PK were examined retrospectively using immunohistochemical analysis to determine if occult epithelial cells were in fact present on the posterior surface of the cornea. Many of these patients were diagnosed with pseudophakic corneal edema or graft failure and had undergone multiple intraocular surgical procedures.
Purpose: To evaluate patients who developed ectasia with no apparent preoperative risk factors.
Methods: Potential cases of patients who developed ectasia without apparent risk factors were identified by contacting participants in the Kera-Net (n = 580), ASCRS-Net (n = 450), and ISRS/AAO ISRS-Net (n = 525) internet bulletin boards from April to October 2003. Cases were included if ectasia developed after laser in situ keratomileusis in the absence of apparent preoperative risk factors.
Purpose: Long-term evaluation of dihematoporphyrin ether (DHE) safety and efficacy as photodynamic therapy (PDT) for patients with corneal neovascularization (KNV).
Design: Prospective multi-center interventional case series.
Methods: Seven patients were enrolled after Institutional Review Board approval and a detailed informed consent were obtained.
Purpose: To evaluate the safety and efficacy of flap suturing with proparacaine application for the management of recurrent epithelial ingrowth following laser in situ keratomileusis (LASIK).
Setting: Private consultation practice and Department of Ophthalmology, Rush University, Chicago, Illinois, USA.
Methods: Six eyes of 5 patients with recurrent epithelial ingrowth had flap lifting followed by debridement of interface epithelial cells, interface application of proparacaine, and the placement of interrupted 10-0 nylon sutures.
Purpose: To evaluate the efficacy of transepithelial phototherapeutic keratectomy/photorefractive keratectomy (PTK/PRK) with prophylactic mitomycin-C for the treatment of refractive errors and maintenance of corneal clarity following flap complications in laser in situ keratomileusis (LASIK).
Setting: Outpatient tertiary care center, Chicago, Illinois, USA.
Methods: Ten eyes of 10 patients with LASIK flap complications had transepithelial PTK/PRK for correction of ametropia.