Publications by authors named "Rands M"

Article Synopsis
  • - Prostate cancer is a serious global health issue with low survival rates in advanced stages, often progressing to a castration-resistant form after initial treatment failure.
  • - Current treatments mainly target androgen receptors, but there's a pressing need for new drugs that focus on the oncogenes involved in prostate cancer development, particularly E-26 transformation-specific (ETS) transcription factors.
  • - Research into various targeted therapies, including small molecules and nucleic acids, shows promise in inhibiting ETS activity, which could reduce tumor growth, though more studies are needed to understand their effects on both tumor and non-tumor tissues.
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The continued growth of human populations and of per capita consumption have resulted in unsustainable exploitation of Earth's biological diversity, exacerbated by climate change, ocean acidification, and other anthropogenic environmental impacts. We argue that effective conservation of biodiversity is essential for human survival and the maintenance of ecosystem processes. Despite some conservation successes (especially at local scales) and increasing public and government interest in living sustainably, biodiversity continues to decline.

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We identified 100 scientific questions that, if answered, would have the greatest impact on conservation practice and policy. Representatives from 21 international organizations, regional sections and working groups of the Society for Conservation Biology, and 12 academics, from all continents except Antarctica, compiled 2291 questions of relevance to conservation of biological diversity worldwide. The questions were gathered from 761 individuals through workshops, email requests, and discussions.

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A role has been delineated for both bcl-2 and NF-kappa B in mediating an adaptive survival response to the TNF-alpha signaling pathway for apoptosis. Additionally, we and others have demonstrated a role for bcl-2 upregulation during progression of prostate cancer and acquisition of androgen-independent growth (T. J.

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The indirect contribution terrestrial isopods make to decomposition processes by stimulating microbial activites has been quantified in laboratory experiments. The extent to which microbial metabolism is enhanced as a result of the passage of Betula pendula leaf litter through the alimentary system of isopods was measured for both freshly fallen and decayed leaves. Faeces derived from 1 g freshly fallen litter lost 75 mg g D.

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