In-depth characterization of the salivary adenoid cystic carcinoma transcriptome with emphasis on dominant cell type.

Background: Adenoid cystic carcinoma (ACC), 1 of the most common salivary gland malignancies, arises from the intercalated ducts, which are composed of inner ductal epithelial cells and outer myoepithelial cells. The objective of this study was to determine the genomic subtypes of ACC with emphasis on dominant cell type to identify potential specific biomarkers for each subtype and to improve the understanding of this disease.

Methods: A whole-genome expression study was performed based on 42 primary salivary ACCs and 5 normal salivary glands.

Identification of a gene signature for rapid screening of oral squamous cell carcinoma.

Purpose: Oral cancer is a major health problem worldwide and in the U.S. The 5-year survival rate for oral cancer has not improved significantly over the past 20 years and remains at approximately 50%.

Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival.

Background: Survival has decreased among patients with laryngeal cancer during the past 2 decades in the United States. During this same period, there has been an increase in the nonsurgical treatment of laryngeal cancer.

Objective: The objectives of this study were to identify trends in the demographics, management, and outcome of laryngeal cancer in the United States and to analyze factors contributing to the decreased survival.