Publications by authors named "Randall Odem"

Purpose: Implantation failure is a major limiting factor of successful in vitro fertilization (IVF). The objective of this study was to determine if endometrial mechanical stimulation (EMS) by endometrial biopsy in the luteal phase of the cycle prior to embryo transfer (ET) improves clinical outcomes in an unselected subfertile population.

Methods: Double-blind, randomized controlled trial of EMS versus sham biopsy and odds of clinical pregnancy after IVF and embryo transfer.

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Objective: To demonstrate a unique case of direct ultrasound-guided follicle aspiration at time of a laparotomy in a patient with Mayer-Rokitansky-Küster-Hauser Syndrome.

Design: Video presentation.

Setting: Academic fertility center PATIENT(S): A 32-year-old gravida 0 with Mayer-Rokitansky-Küster-Hauser Syndrome and bilateral ovarian masses presented as a fertility preservation consult from gynecologic oncology due to the possibility of bilateral oophorectomy.

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Standardization improves performance and safety. A template for standardizing the embryo transfer procedure is presented here with 12 basic steps supported by published scientific literature and a survey of common practice of SART programs; it can be used by ART practices to model their own standard protocol.

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Objective: To determine the effect of short-term combined oral contraceptive (OCP) use on antral follicle count (AFC) in obese and nonobese women with infertility.

Study Design: A retrospective review of women who had an AFC (sum of 2-10 mm bilateral ovarian follicles on basal follicular phase ultrasound) measured before and after short-term OCP use between the years 2005 and 2010. These were women who had a baseline AFC measurement during an unsuccessful controlled ovarian hyperstimulation/intrauterine insemination who were then placed on OCPs prior to an in vitro fertilization (IVF) cycle that included a subsequent AFC measurement at baseline.

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The aim of this study was to determine whether practice in states with infertility insurance mandates is associated with physician-reported practice patterns regarding hydrosalpinx management in assisted reproduction clinics. A cross-sectional, internet-based survey of 442 members of Society for Reproductive Endocrinology and Infertility or Society of Reproductive Surgeons was performed. Physicians practising in states without infertility insurance mandates were more likely to report performing diagnostic surgery after an inconclusive hysterosalpingogram than physicians practising in states with mandates (RR 1.

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Objective: To determine whether IVF modifies the effect of fetal sex on growth.

Design: Retrospective cohort study.

Setting: Tertiary care center and related facilities.

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Objective: Determine whether testicular sperm extractions and pregnancy outcomes are influenced by male and female infertility diagnoses, location of surgical center and time to cryopreservation.

Patients: One hundred and thirty men undergoing testicular sperm extraction and 76 couples undergoing 123 in vitro fertilization cycles with testicular sperm.

Outcome Measures: Successful sperm recovery defined as 1-2 sperm/0.

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Objective: Sperm banking is an effective method to preserve fertility, but is not universally offered to males facing gonadotoxic treatment in the United States. We compared the disposition and semen parameters of cryopreserved sperm from individuals referred for sperm banking secondary to a cancer diagnosis to those of sperm from men banking for infertility reasons.

Study Design: We performed a retrospective cohort study that reviewed 1118 records from males who presented to bank sperm at Washington University between 1991 and 2010.

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Article Synopsis
  • - This study investigates the factors that predict inadequate endometrial cavity thickness (less than 8 mm) during frozen embryo transfer (FET) cycles among 274 women who had their first endometrial preparation with estradiol.
  • - The research found that factors such as lower body mass index, nulliparity, previous hysteroscopy, and thinner endometrial lining in fresh cycles were linked to inadequate thickness in FET cycles, while age and duration of estrogen treatment were not.
  • - A fresh cycle endometrial thickness of 11.5 mm or less is a significant indicator for potential issues in a subsequent FET cycle, suggesting that women in this category may need extra support to achieve appropriate endometrial
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Objective: To describe the management of hydrosalpinges among Society for Reproduction Endocrinology and Infertility (SREI)/Society of Reproductive Surgeons (SRS) members.

Design: Cross-sectional survey of SREI/SRS members.

Setting: Academic and private practice-based reproductive medicine physicians.

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Objective: To study and describe the use of social networking websites among Society for Assisted Reproductive Technology (SART) member clinics.

Design: Cross-sectional study.

Setting: University-based practice.

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Objective: To determine whether fetal size differences exist between matched fertile and infertile women and among women with infertility achieving pregnancy through various treatment modalities.

Design: Retrospective cohort study with propensity score analysis.

Setting: Tertiary care center and affiliated community hospitals.

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Objective: To analyze relationships between serum free fatty acid (FFA) concentrations and pregnancy.

Design: Prospective cohort.

Setting: University hospital.

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Objective: To determine if follicular free fatty acid (FFA) levels are associated with cumulus oocyte complex (COC) morphology.

Design: Prospective cohort study.

Setting: University in vitro fertilization (IVF) practice.

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To determine the impact of maternal metabolic state on oocyte development in women undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), we retrospectively analyzed a cohort of women with PCOS undergoing IVF/ICSI from 2008-2009 in a university-based fertility center. We determined that women with PCOS and obesity have smaller oocytes than control subjects, and that when further subdivided by body mass index, both PCOS and obesity independently influence oocyte size.

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Few data exist regarding IVF in women who have undergone bariatric surgery. Our experience with five patients suggests that IVF is a safe and effective fertility treatment for these women, although special considerations should be made when treating patients who have undergone bariatric surgery. Considering the type of bypass procedure the patient underwent is particularly important should a patient develop concerning symptoms during her IVF cycle.

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Objective: To gain a better understanding of factors influencing clinicians' embryo transfer practices.

Design: Cross-sectional survey.

Setting: Web-based survey conducted in December 2008 of individuals practicing IVF in centers registered with the Society for Assisted Reproductive Technology (SART).

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Background: Qualitative point-of-care (POC) tests for human chorionic gonadotropin (hCG) vary in their ability to detect purified hCG variants and there is data to suggest that over-the-counter (OTC) devices might also display similar variability. This could potentially influence the detection of urine hCG in early pregnancy.

Methods: Six OTC devices were tested for their ability to detect 5 hCG variants.

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Objective: To review our patients' decisions for disposition of their cryopreserved embryos and compare the findings with those reported in the scientific literature. Patients who no longer wish to store their cryopreserved embryos have three choices: discarding, donation to research, or donation to someone else for initiation of a pregnancy.

Design: Retrospective review of patient records from January 2002 to July 2007 to determine preferences for embryo disposition.

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Objective: To determine whether assisted hatching is beneficial to IVF patients younger than 38 years whose embryos have a thickened zona pellucida (ZP).

Design: Prospective, randomized, double-blinded, crossover study.

Setting: University-based infertility center.

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Objective: To determine whether morbid obesity is associated with decreased pregnancy and live birth rates after IVF in women with polycystic ovary syndrome (PCOS).

Design: Retrospective cohort study.

Setting: University-based fertility center.

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Single-embryo transfer (SET) removes the risk of multiples in in vitro fertilization (IVF), but women with unfavorable IVF prognosis have been dissuaded from SET despite their desire to avoid multiples. In our clinic, 54% of the women who requested SET delivered healthy singletons, even though only two of them had met the American Society for Reproductive Medicine's SET guidelines. This demonstrates the value of encouraging patient-driven SET.

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Objective: To compare the incidence of multiple gestation following treatment with clomiphene citrate (CC), metformin (MET) or gonadotropins in polycystic ovary syndrome (PCOS) patients undergoing ovulation induction.

Study Design: This was a retrospective, cohort study performed in an academic reproductive endocrine practice. PCOS patients presenting for first-trimester ultrasound were identified and assigned to 1 of 3 groups: CC-resistant patients who conceived after use of metformin +/- CC (group A), CC-resistant patients who conceived after gonadotropins (group B) and PCOS patients who conceived with CC only (group C).

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