Uterine rejection after allogeneic uterus transplantation in the rat is effectively suppressed by tacrolimus.

Objective: To evaluate the effects of the immunosuppressant tacrolimus on rejection of a transplanted uterus and on uterine expression of markers of inflammation and implantation.

Design: Experimental study.

Setting: University laboratory.

Transplantation of the uterus in sheep: methodology and early reperfusion events.

Aim: Uterine transplantation is developing into a clinical treatment for uterine factor infertility. An animal model with a similar uterus size and vessels to humans and with pregnancy extending over several months would be beneficial for research on uterine transplantation. The aim of this study was to develop and evaluate autotransplantation of the sheep uterus to an orthotopic position in the pelvis.

Auto-transplantation of the uterus in the domestic pig (Sus scrofa): Surgical technique and early reperfusion events.

Aim: To develop a method for auto-transplantation of the uterus in the pig and to evaluate the early reperfusion events after short-term cold ischemia.

Methods: The bicornate uterus, with the cervix but without ovaries, was dissected and isolated with its bilateral feeding and draining vessels. The uterine arteries were cannulated in situ and the uterus was flushed with heparinized Ringer Acetate.