Thermal Effects on DNA Degradation in Blood and Seminal Stains: Forensic View.

Unlabelled: Forensic investigations using DNA analysis have been grown rapidly. Samples retrieved from crime scene may be exposed to different conditions before proceeding. This study aimed to evaluate the effect of different grades of temperature and burn on DNA extraction and typing.

Role of oxidative stress and inducible nitric oxide synthase in morphine-induced tolerance and dependence in mice. Effect of alpha-lipoic acid.

In this study, the possible role of oxidative stress and nitric oxide (NO) synthase isoforms in the development of morphine tolerance and dependence, and effect of alpha-lipoic acid on these parameters were investigated in mice. The development of morphine tolerance as measured by the hot plate test and dependence, as assessed by naloxone-precipitated withdrawal manifestations, produced an increase in brain glutamate and malondialdehyde (MDA) levels and NO production as well as a decrease in brain intracellular reduced glutathione (GSH) level and glutathione peroxidase (GSH-Px) activity. Also, the development of these syndromes increased inducible but not neuronal NO synthase mRNA and protein expressions in mice brain.

Alpha-lipoic acid protects against potassium cyanide-induced seizures and mortality.

This study was proposed to investigate the potential protective effect of alpha-lipoic acid (α-LA) against potassium cyanide (KCN)-induced seizures and lethality in mice. The intraperitoneal ED(50) value of KCN, as measured by induction of clonic and tonic seizures was increased by pretreatment of mice with α-LA (25, 50 and 100 mg/kg) intraperitoneally in a dose-dependent manner. Similarly, the intraperitoneal LD(50) value of KCN, based on 24h mortality, was increased by pretreatment with α-LA in a dose-dependent manner.

Subchronic toxicity of cannabis leaves on male albino rats.

Cannabis is the most commonly abused drug in the world. In Egypt, the Anti Narcotic General Administration showed that the narcotics problem costs the Egyptian economy approximately 800 million dollars annually. LD(50), lethal dose that kills 50% of the treated animals, of the bango was determined and then selected groups of rats were given tenth of LD(50) for 90 days.

Risk factors for bango abuse in upper Egypt.

Cannabis is the most commonly abused drug in the world. In Egypt, the Anti Narcotic General Administration, showed that the narcotics problem costs the Egyptian economy approximately 800 million dollars annually. The present study was designed to determine the risk factors that lead to bango abuse among secondary school students and drivers in Assiut province.

Identification of sex depending on radiological examination of foot and patella.

Forensic anthropology involves the building of an antemortem profile of an individual from skeletal remains. This includes sex, race determination, and age and stature estimation. Because most bones that are conventionally used for sex determination are often recovered either in a fragmented or incomplete state, it has become necessary to use denser bones that are often recovered intact, eg, the patella, calcaneus, and talus.

The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage.

The potential protective role of alpha-lipoic acid (alpha-LA) in acetaminophen (APAP)-induced hepatotoxicity and nephrotoxicity was investigated in rats. Pretreatment of rats with alpha-LA (100mg/kg) orally protected markedly against hepatotoxicity and nephrotoxicity induced by an acute oral toxic dose of APAP (2.5 g/kg) as assessed by biochemical measurements and by histopathological examination.

Attenuation of morphine tolerance and dependence by aminoguanidine in mice.

The effect of aminoguanidine, an inducible nitric oxide synthase (iNOS) inhibitor, on morphine-induced tolerance and dependence in mice was investigated in this study. Acute administration of aminoguanidine (20 mg/kg, p.o.

Estimation of human body built in Egyptians.

Identification of an unknown body and prediction of growth from specific body measurements are very important tasks in the fields of physical anthropology and forensic medicine. Height and weight are two factors among others required to establish individuality of an unidentified body. In the present work, an attempt has been made to calculate the stature and weight from percutaneous tibial length and bimalleolar breadth.

Antidiabetic activity and toxicity of Zizyphus spina-christi leaves.

The effect of the butanol extract of Zizyphus spina-christi (L.), Willd (Rhamnaceae) leaves and its major saponin glycoside, christinin-A, on the serum glucose and insulin levels was studied in non-diabetic control, type-I (insulin-dependent) and type-II (non-insulin-dependent) diabetic rats. Pretreatment either with 100 mg/kg butanol extract or christinin-A potentiated glucose-induced insulin release in non-diabetic control rats.