Publications by authors named "Randa A Mabrouk"
Unlabelled: Framingham risk score (FRS) is a widely used tool to identify asymptomatic individuals who are at risk to cardiovascular disease. We aimed to investigate the association between subclinical atherosclerosis and FRS among elderly with both type 2 diabetes mellitus and healthy participants.
Methods: As case-control study was done on 58 men and women, who had type 2 diabetes mellitus, and in 59 age and gender matched control participants.
Article Synopsis
- Hypertension is a key risk factor for atherosclerosis, and increased carotid artery intima-media thickness (IMT) serves as a noninvasive indicator of overall atherosclerotic disease.
- The study focused on older adults, examining 60 hypertensive individuals alongside 30 healthy controls, revealing that hypertensive patients had higher levels of body mass index, cholesterol, and inflammatory marker hs-CRP.
- Findings indicated that higher hs-CRP levels and longer hypertension duration correlated positively with increased carotid IMT, suggesting inflammation plays a more significant role in arterial thickening than other traditional risk factors.
The role of urokinase plasminogen activator receptor (uPAR) and c-erbB-2 in breast and ovarian cancer was investigated. Eighty patients of breast and ovarian cancer and benign lesions, as well as twenty normal controls were evaluated for the expression of c-erbB-2 by Western blotting and uPAR levels by ELISA. The c-erbB-2 and uPAR showed a significant increase in both types of cancer investigated compared to normal control and benign lesions.
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