Publications by authors named "Randa A Abdelnaser"
Article Synopsis
- HIV-1-infected individuals on antiretroviral therapy still face higher risks of non-AIDS-related health issues due to ongoing chronic inflammation, marked by specific changes in monocytes like increased CD16 subsets and elevated soluble markers sCD163 and sCD14.
- The study reveals that IL-10, an anti-inflammatory cytokine, can activate monocytes by increasing CD16 and other soluble markers through multiple signaling pathways, including Stat3 and AMPK.
- Additionally, the HIV-1 protein Nef promotes the production of IL-10 in macrophages, suggesting that IL-10 contributes to the persistent activated state of monocytes in individuals who have achieved viral suppression.