Publications by authors named "Rana Suliman"
A screen of repurposed drugs identifies AMHR2/MISR2 agonists as potential contraceptives.
Proc Natl Acad Sci U S A
April 2022
We identified the anti-Mullerian hormone (also known as Müllerian inhibiting substance or MIS) as an inhibitory hormone that induces long-term contraception in mammals. The type II receptor to this hormone, AMHR2 (also known as MISR2), represents a promising druggable target for the modulation of female reproduction with a mechanism of action distinct from steroidal contraceptives. We designed an in vitro platform to screen and validate small molecules that can activate MISR2 signaling and suppress ovarian folliculogenesis.
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- The Mullerian ducts are crucial for developing the female reproductive tract, but regress in males due to Mullerian Inhibiting Substance (MIS).
- In females, certain cells (Misr2+) that help regulate this process remain, but their exact role in uterus development is unclear.
- Research shows that administering MIS to newborn rodents affects these Misr2+ cells, disrupting the formation of uterine tissue and leading to issues like reduced uterine size and infertility in adult females.