Comparison between Effect of Bisphosphonates, Concentrated Growth Factors or Combination on Rabbits' Tibial Bone Defects Healing: An Experimental Study.

Aim: This study was designed to evaluate the effect of bisphosphonates (BIS) or concentrated growth factors (CGF) or a combination of them on bone defect healing.

Materials And Methods: Bone defects of 3-mm width and 6-mm depth were prepared in 24 rabbit tibias unilaterally, then randomly divided into the following four equal groups: 1. Group I: No treatment 2.