Publications by authors named "Rana Amin"
Corrigendum: Efficacy and safety of Janus kinase inhibitors in non-infectious inflammatory ocular diseases: a prospective cohort study from the international AIDA network registries.
Front Med (Lausanne)
September 2024
Article Synopsis
- The article discusses corrections to research findings initially published.
- It emphasizes the importance of accuracy in scientific communication.
- This correction aims to ensure that readers are aware of any significant changes to the original data and conclusions.
Article Synopsis
- The growing limitations of traditional lubricants have led to an increase in the demand for biolubricants, which are sustainable, biodegradable, and non-toxic alternatives derived from renewable resources like vegetable oils and animal fats.
- In this study, a novel approach was taken by producing biolubricants using biodiesel from blending animal fats and waste cooking oil, optimized using response surface methodology (RSM) to achieve a high yield of 91.56% under specific reaction conditions.
- The resulting biolubricant showed promising properties such as a pour point of -9 °C and a flash point of 192 °C, meeting favorable standards for lubricants, and the production process was simulated using Aspen Plus for further
Efficacy and safety of Janus kinase inhibitors in non-infectious inflammatory ocular diseases: a prospective cohort study from the international AIDA network registries.
Front Med (Lausanne)
August 2024
Article Synopsis
- Non-infectious inflammatory ocular diseases can be challenging to diagnose and manage, often requiring systemic immunosuppressive therapy; JAK inhibitors may offer a new treatment approach.
- A study with 12 patients showed that systemic diseases were present in 67% of cases, and various JAK inhibitors were administered, with an average treatment duration of 8.6 months.
- Results indicated complete ocular disease control in all patients after treatment, with a significant reduction in the incidence of ocular flares, confirming the efficacy and safety of JAK inhibitors for these conditions.
Purpose: The clinical relevance of human leukocyte antigen (HLA) subtypes such as HLA-B51 on Behçet's disease (BD)-related uveitis and non-infectious uveitis (NIU) unrelated to BD remains largely unknown.
Methods: Data were prospectively collected from the International AIDA Network Registry for BD and for NIU. We assessed differences between groups (NIU unrelated to BD and positive for HLA-B51, BD-related uveitis positive for HLA-B51 and BD-related uveitis negative for HLA-B51) in terms of long-term ocular complications, visual acuity (VA) measured by best corrected visual acuity (BCVA), anatomical pattern, occurrence of retinal vasculitis (RV) and macular edema over time.
Article Synopsis
- Many biological drug patents have expired, leading to the development of biosimilar agents (BIOs), but their use in children raises concerns, prompting a study on their efficacy and safety for treating pediatric non-infectious uveitis (NIU).
- Data collected from pediatric patients treated with TNF inhibitors BIOs showed a significant decrease in flare-ups and ocular complications, as well as a reduction in the need for glucocorticoids during treatment.
- The study included 47 patients, demonstrating strong treatment retention rates and maintaining visual acuity throughout the therapy, while only recording a few minor adverse events.
Krüppel-like factor 4 (KLF4), a zinc finger transcription factor, is found in different human tissues and shows diverse regulatory activities in a cell-dependent manner. In the brain, KLF4 controls various neurophysiological and neuropathological processes, and its contribution to various neurological diseases has been widely reported. Parkinson's disease (PD) is an age-related neurodegenerative disease that might have a connection with KLF4.
View Article and Find Full Text PDFIn July 2022, a new virus called Langya virus (LayV) was discovered in China in patients who had a fever. This virus is a type of Henipavirus (HNV) and is considered a potential threat as it could spread from animals to humans. It causes respiratory disease with symptoms including fever, coughing, and fatigue and is closely linked to two other henipaviruses that are known to infect humans, namely and viruses.
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- The study investigates the effectiveness of adalimumab (ADA), a tumor necrosis factor inhibitor, in treating pediatric patients with non-infectious non-anterior uveitis, where scientific evidence is currently limited.
- Data from the AutoInflammatory Disease Alliance (AIDA) registry were analyzed, involving 21 patients who received ADA treatment for various types of uveitis.
- Results showed significant improvements, with a decrease in ocular inflammation, fewer ocular flares, and reduced glucocorticoid usage, indicating ADA's potential as an effective therapy for these patients.
Purpose: To describe the surgical management of presumed trematode-induced granulomatous intermediate uveitis (PTIGIU) not responding to medical treatment in controlling the inflammation.
Methods: A prospective, interventional, single-center study in which patients with a history of fresh canal water contact and PTIGIU were enrolled. All patients underwent lensectomy-pars plana vitrectomy (PPV) and post-operative control of inflammation, functional and anatomical outcomes were assessed.
To evaluate the retinal vasculature in psoriasis patients and detect if metabolic syndrome is an additional risk factor. This cross-sectional analytic study was carried out on 80 eyes of 80 subjects; 28 eyes with psoriasis only (PS group), 12 eyes with additional metabolic syndrome to psoriasis (PMS group) and 40 eyes healthy controls (HS). The retinal capillary plexuses were evaluated by OCTA.
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- Behçet's Disease (BD), also known as "The Silk Road Disease," is characterized by recurrent mouth and genital ulcers, along with uveitis, and is becoming prominent in clinics focused on ocular inflammatory diseases.
- * The review discusses the clinical features of BD, diagnostic strategies, and the emerging role of the human microbiome in its pathophysiology, particularly with findings from recent studies.
- * Advances in treatment options, including cytokine-blocking biologics and the impact of the COVID-19 pandemic on BD's management and morbidity, are also examined.
Purpose: To assess the safety and efficacy of combining nasal goniotomy with temporal trabeculotomy in the management of primary congenital glaucoma.
Design: Case series.
Methods: Fifteen eyes of eleven children (3-12 months old at presentation) were enrolled in this study after the establishment of PCG diagnosis based on the criteria placed by the World Glaucoma Association.
Article Synopsis
- The paper discusses the creation of the AIDA International Registry, aimed at tracking data for pediatric and adult patients with non-infectious uveitis.
- This registry collects a wide range of standardized information through a digital platform called REDCap, focusing on patient demographics, clinical data, and treatment details to enhance research quality.
- As of late 2021, 95 centers from 19 countries are participating, and the registry is expected to help in global research collaborations and improve understanding of non-infectious uveitis.
Article Synopsis
- - The article discusses the creation and implementation of a global registry by the AIDA Network to gather data from both pediatric and adult patients with immune-mediated scleritis.
- - Using the REDCap tool, the registry collects a wide range of data securely, while allowing for adaptability as scientific knowledge grows and enabling collaboration with other registries for sustainability.
- - Since its inception, the registry has engaged 99 centers across 20 countries, collecting comprehensive data to enhance research and improve clinical management of this rare ocular inflammatory condition.
Waardenburg syndrome (WS) is a genetic disorder resulting in anomalies of derivatives of neural crest cells during development. Patients tend to have variable degrees of pigmentary defects affecting skin, hair, and irides in addition to hearing loss and possible systemic neurological associations. Elevation of the intraocular pressure has been reported in several adult patients with WS.
View Article and Find Full Text PDFBilateral acute depigmentation of the iris in two siblings simultaneously.
Am J Ophthalmol Case Rep
June 2018
Purpose: To report the first simultaneous onset of bilateral acute depigmentation of the iris (BADI) in two siblings.
Observations: Two sisters presented with bilateral ocular pain, redness and light sensitivity. Examination revealed bilateral circulating pigment in the anterior chamber with pigment dusting on backs of the corneas, patchy iris depigmentation and heavy pigment deposition in the angle.