A Challenging Case of Primary Membranous Nephropathy with Renal Cell Carcinoma - Double Whammy.

Membranous nephropathy is the most common cause of nephrotic syndrome in adults. It can be associated with malignancy especially in elderly patients, however; sometimes it is difficult to distinguish. Hereby we present an interesting case of primary membranous nephropathy in a patient with renal cell carcinoma.

Manifestations of a glacier surge in central Himalaya using multi-temporal satellite data.

Our understanding of identifying and monitoring surge-type glacier distribution patterns, fluctuations, periodicities, and occurrence mechanism under the changing climate is challenging and scarce due to small numbers, limitations on the spatiotemporal coverage of remote sensing observations, and insufficient field-based glaciological data from the High Mountain Asia. The surging glaciers have caused major hazards, and their movement can destroy peripheral and downstream areas like roads, connecting bridges, villages, and hydropower stations and trigger a glacial lake outburst flood or form a dammed (moraine or ice) lake in High Mountain Asia (HMA) in the recent past. Many glaciers have experienced a mass loss and retreat due to ongoing climate change in HMA in recent decades, whereas studies conducted in the Karakorum, Pamir, Tien Shan, and Kunlun Shan regions have reported the surging of the glaciers.

Nanomechanical inhomogeneities in CVA-deposited titanium nitride thin films: Nanoindentation and finite element method investigations.

Refractory metals that can withstand at high temperatures and harsh conditions are of utmost importance for solar-thermal and energy storage applications. Thin films of TiN have been deposited using cathodic vacuum arc deposition at relatively low temperatures ∼300 °C using the substrate bias ∼ -60 V. The nanomechanical properties of these films were investigated using nanoindentation and the spatial fluctuations were observed.

Measurement of indoor radioactivity and dose derived from 222Rn, 220Rn and EECs by using SSNTD based technique.

Alpha flux radiated from 222Rn, 220Rn and progeny is the primary contributor of natural radioactivity to the inhabitants in the ambient atmosphere. The annual indoor 222Rn and 220Rn concentrations were found to be 85 ± 43 and 84 ± 36 Bq m-3, respectively. The estimated annual indoor 222Rn and 220Rn concentration is below to reference value of 100 Bq m-3 suggested by WHO.

Tuning the plasmonic resonance in TiN refractory metal.

Plasmonic coatings can absorb electromagnetic radiation from visible to far-infrared spectrum for the better performance of solar panels and energy saving smart windows. For these applications, it is important for these coatings to be as thin as possible and grown at lower temperatures on arbitrary substrates like glass, silicon, or flexible polymers. Here, we tune and investigate the plasmonic resonance of titanium nitride thin films in lower thicknesses regime varying from ~ 20 to 60 nm.

H-theorem and boundary conditions for two-temperature model: Application to wave propagation and heat transfer in polyatomic gases.

Polyatomic gases find numerous applications across various scientific and technological fields, necessitating a quantitative understanding of their behavior in nonequilibrium conditions. In this study, we investigate the behavior of rarefied polyatomic gases, particularly focusing on heat transfer and sound propagation phenomena. By utilizing a two-temperature model, we establish constitutive equations for internal and translational heat fluxes based on the second law of thermodynamics.

Resistive switching and battery-like characteristics in highly transparent TaO/ITO thin-films.

Highly transparent resistive-switching (RS) devices were fabricated by growing amorphous tantalum pentoxide (a-TaO) and indium tin oxide (a-ITO) thin films on barium-borosilicate glass (7059) substrates, using electron beam evaporation. These layers exhibited the transmittance greater than ~ 85% in the full visible region and showed RS behavior and battery-like IV characteristics. The overall characteristics of RS can be tuned using the top electrode and the thickness of a-TaO.

Fundamental solutions of an extended hydrodynamic model in two dimensions: Derivation, theory, and applications.

The inability of the Navier-Stokes-Fourier equations to capture rarefaction effects motivates us to adopt the extended hydrodynamic equations. In the present work, a hydrodynamic model, which consists of the conservation laws closed with the recently propounded coupled constitutive relations (CCR), is utilized. This model is referred to as the CCR model and is adequate for describing moderately rarefied gas flows.

Inhomogeneous superconductivity and quasilinear magnetoresistance at amorphous LaTiO/SrTiOinterfaces.

We have studied the transport properties of LaTiO/SrTiO(LTO/STO) heterostructures. In spite of 2D growth observed in reflection high energy electron diffraction, Transmission Electron Microscopy images revealed that the samples tend to amorphize. Still, we observe that the structures are conducting, and some of them exhibit high conductance and/or superconductivity.

Coupled constitutive relations: a second law based higher-order closure for hydrodynamics.

In the classical framework, the Navier-Stokes-Fourier equations are obtained through the linear uncoupled thermodynamic force-flux relations which guarantee the non-negativity of the entropy production. However, the conventional thermodynamic descrip- tion is only valid when the Knudsen number is sufficiently small. Here, it is shown that the range of validity of the Navier-Stokes-Fourier equations can be extended by incorporating the nonlinear coupling among the thermodynamic forces and fluxes.

Evaporation Boundary Conditions for the Linear R13 Equations Based on the Onsager Theory.

Due to the failure of the continuum hypothesis for higher Knudsen numbers, rarefied gases and microflows of gases are particularly difficult to model. Macroscopic transport equations compete with particle methods, such as the Direct Simulation Monte Carlo method (DSMC), to find accurate solutions in the rarefied gas regime. Due to growing interest in micro flow applications, such as micro fuel cells, it is important to model and understand evaporation in this flow regime.

Nodal involvement in Oral Squamous Cell Carcinoma (SCC) patients with and without Oral Sub Mucous Fibrosis (OSMF): A Comparative Study.

Aim: The aim of the study is to compare and evaluate neck node status of oral cancer patients with and without Oral Sub Mucous Fibrosis (OSMF) treated surgically.

Methodology: A total of 50 patients of Indian origin who were diagnosed with Squamous Cell Carcinoma (SCC) of oral cavity and had not taken any prior treatment were included in the study. Clinical examination and metastatic workup was done for all patients.

Malroatation of gut with superior mesenteric artery syndrome and multiple jejunal diverticula presenting as acute intestinal obstruction in 6th decade: A rare case report.

Introduction: Intestinal malrotation is a disease of neonates and young children presenting as acute intestinal obstruction. Presentation of malrotation in elderly patients with intestinal obstruction is quite rare with only a few cases reported in literature. We report a case of intestinal malrotation presenting as acute obstruction in sixth decade.

The future potential for cocaine vaccines.

Introduction: Addiction to cocaine is a major problem around the world, but especially in developed countries where the combination of wealth and user demand has created terrible social problems. Although only some users become truly addicted, those who are often succumb to a downward spiral in their lives from which it is very difficult to escape. From the medical perspective, the lack of effective and safe, non-addictive therapeutics has instigated efforts to develop alternative approaches for treatment, including anticocaine vaccines designed to block cocaine's pharmacodynamic effects.

Hapten optimization for cocaine vaccine with improved cocaine recognition.

In the absence of any effective pharmacotherapy for cocaine addiction, immunotherapy is being actively pursued as a therapeutic intervention. While several different cocaine haptens have been explored to develop anticocaine antibodies, none of the hapten was successfully designed, which had a protonated tropane nitrogen as is found in native cocaine under physiological conditions, including the succinyl norcocaine (SNC) hapten that has been tested in phase II clinical trials. Herein, we discuss three different cocaine haptens: hexyl norcocaine (HNC), bromoacetamido butyl norcocaine (BNC), and succinyl butyl norcocaine (SBNC), each with a tertiary nitrogen structure mimicking that of native cocaine which could optimize the specificity of anticocaine antibodies for better cocaine recognition.

Evaluation of efficacy of arthrocentesis (with normal saline) with or without sodium hyaluronate in treatment of internal derangement of TMJ - A prospective randomized study in 20 patients.

Purpose: To compare the outcome of arthrocentesis alone and arthrocentesis with sodium hyaluronate in internal derangement of TMJ.

Materials And Methods: 20 patients of disc displacement with reduction of TMJ were randomized into 2 experimental groups. Control group of patients received arthrocentesis alone and study group of patients received arthrocentesis with sodium hyaluronate.

Comparative Study of Different Treatment Options of Grade III and IV Diabetic Foot Ulcers to Reduce the Incidence of Amputations.

THIS STUDY AIMS TO COMPARE THE EFFICACY OF ANTISEPTIC DRESSINGS, HYPERBARIC OXYGEN THERAPY, AND RECOMBINANT HUMAN PLATELET DERIVED GROWTH FACTOR (RHPDGF) FOR TWO REASONS: i) to reduce the incidence of lower limb amputations in diabetic foot ulcer; ii) to limit the duration of stay in the hospital. A prospective randomized trial was conducted on 60 patients with stage III and IV diabetic foot ulcers (International Association of Enterostomal Therapy classification) and patients were divided randomly in three different therapy groups - antiseptics, hyperbaric oxygen therapy, recombinant platelet derived growth factor, with 20 patients in each group. Patients were managed initially on inpatient and then on outpatient basis till the ulcer healed completely.

Treatment of recurrent TMJ dislocation in geriatric patient by autologous blood - A technique revisited.

A number of techniques have been advocated for the treatment of recurrent temporomandibular joint dislocation. Autologous blood injection around the articular capsule and/or into the articular cavity, which is one of the treatment modality, was recently reintroduced. We report a case of 82-year-old female with bilateral recurrent temporomandibular joint dislocation, treated by technique of autologous blood injection.

Dose-dependent changes in the locomotor responses to methamphetamine in BALB/c mice: low doses induce hypolocomotion.

The overall goal of the present study was to determine the effects of different doses of (+)-methamphetamine (meth) on locomotor activity of Balb/C mice. Four experiments were designed to test a wide range of meth doses in BALB/c female mice. In Experiment 1, we examined locomotor activity induced by an acute administration of low doses of meth (0.

Spontaneous rupture of kidney: a rare presentation of nephrolithiasis.

Spontaneous rupture of kidney is a rare clinical entity. A 35-year-old female presented in emergency with left flank pain and features suggestive of haemorrhagic shock. Investigations showed rupture of kidney with perinephric haematoma.

Evaluation of antifungal activity in essential oil of the Syzygium aromaticum (L.) by extraction, purification and analysis of its main component eugenol.

Antifungal properties of some essential oils have been well documented. Clove oil is reported to have strong antifungal activity against many fungal species. In this study we have evaluated antifungal potential of essential oil of Syzygium aromaticum (L.

Vaccines for cocaine abuse.

Treatments for cocaine abuse have been disappointingly ineffective, especially in comparison with those for some other abused substances. A new approach, using vaccination to elicit specific antibodies to block the access of cocaine to the brain, has shown considerable promise in animal models, and more recently in human trials. The mechanism of action for the antibody effect on cocaine is very likely to be the straightforward and intuitive result of the binding of the drug in circulation by antibodies, thereby reducing its entry into the central nervous system and thus its pharmacological effects.

Substance abuse vaccines.

Conventional substance-abuse treatments have only had limited success for drugs such as cocaine, nicotine, methamphetamine, and phencyclidine. New approaches, including vaccination to block the effects of these drugs on the brain, are in advanced stages of development. Although several potential mechanisms for the effects of antidrug vaccines have been suggested, the most straightforward and intuitive mechanism involves binding of the drug by antibodies in the bloodstream, thereby blocking entry and/or reducing the rate of entry of the drug into the central nervous system.

The future of vaccines in the management of addictive disorders.

Conventional substance abuse treatments have had only limited success. As a result, new approaches, including vaccination to block the effects of drugs such as cocaine, nicotine, methamphetamine, and phencyclidine, are in development. Although a number of possible rationales for the effects of antidrug vaccines have been suggested, the most straightforward and intuitive mechanism would involve binding of the drug by antibodies in the bloodstream, thereby blocking entry or reducing the rate of entry of the drug into the central nervous system.

Activation of refractory T cell responses against hepatitis C virus core protein by ablation of interfering hydrophobic domains.

Hepatitis C virus (HCV) is the major pathogen of chronic hepatitis and liver disease, but currently there are no prophylactic HCV vaccines available. The HCV core protein-encoding sequence is among the most conserved genes in the HCV genome, making it a prime candidate for a component of a vaccine. The core protein localizes to the endoplasmic reticulum (ER) through a C-terminal hydrophobic region that is cotranslationally inserted into the ER membrane.