Chemical and Biological Study of Novel Aplysiatoxin Derivatives from the Marine Cyanobacterium sp.

Since 1970s, aplysiatoxins (ATXs), a class of biologically active dermatoxins, were identified from the marine mollusk , whilst further research indicated that ATXs were originally metabolized by cyanobacteria. So far, there have been 45 aplysiatoxin derivatives discovered from marine cyanobacteria with various geographies. Recently, we isolated two neo-debromoaplysiatoxins, neo-debromoaplysiatoxin G () and neo-debromoaplysiatoxin H () from the cyanobacterium sp.