Publications by authors named "Ran Zhuo"

Glaesserella parasuis (GPS) is the causative agent of Glässer's disease, leading to significant economic losses in the global swine industry. During post-mortem inspection, the main observation in pigs affected by Glässer's disease is the presence of serofibrinous or fibrinopurulent exudate on the mucosal surface. Nevertheless, the mechanism by which fibrinogen is converted into a fibrin clot during Glässer's disease is not fully understood.

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Purpose: To assess the surgical outcomes of Robot-Assisted Laparoscopic Extravesical Ureteral Reimplantation (RALUR-EV) in infants under one year of age with primary vesicoureteral reflux (VUR) as compared to older children.

Materials And Methods: A retrospective analysis was conducted on 48 children with VUR who underwent unilateral or bilateral RALUR-EV between June 2018 and December 2022. Patients were divided into two groups: Group A (25 infants under one year) and Group B (23 children over one year).

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Background: High myopia (HM), characterized by a severe myopic refractive error, stands as a leading cause of visual impairment and blindness globally. HM is a multifactorial ocular disease that presents high genetic heterogeneity. Employing a genetic risk score (GRS) is useful for capturing genetic susceptibility to HM.

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Marine wave energy exhibits significant potential as a renewable resource due to its substantial energy storage capacity and high energy density. However, conventional wave power generation technologies often suffer from drawbacks such as high maintenance costs, cumbersome structures, and suboptimal conversion efficiencies, thereby limiting their potential. The wave power generation technologies based on micro-energy technology have emerged as promising new approaches in recent years, owing to their inherent advantages of cost-effectiveness, simplistic structure, and ease of manufacturing.

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  • Acute myeloid leukemia (AML) is a serious blood cancer that needs new treatment options, and this study highlights phosphodiesterase 3A (PDE3A) as a potential drug target.
  • Researchers found that PDE3A is overexpressed in AML cells compared to normal cells, and high levels of PDE3A are linked to worse outcomes for patients.
  • The study revealed that the PDE3A inhibitor anagrelide (ANA) can effectively suppress the growth of AML cells with high PDE3A levels, especially when used in combination with the chemotherapy drug idarubicin (IDA), which leads to enhanced anti-cancer effects through a process called pyroptosis.
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  • Pediatric T-cell acute lymphoblastic leukemia (T-ALL) still poses significant challenges, including treatment resistance and recurrence, despite advances in prognosis, with LIM domain-binding protein 1 (LDB1) playing a crucial role in this context.
  • * Researchers utilized techniques like shRNA, RNA-Seq, and CUT&Tag to analyze LDB1's function in T-ALL cell lines and uncovered its cooperation with key transcription factors (ERG, ETV6, IRF1) to regulate downstream targets.
  • * The study concludes that LDB1 is essential for T-ALL cell proliferation and survival, specifically regulating the significant target gene MYB, thus providing insights into its role in T-ALL progression.*
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We present the first described case of bacteremia due to Butyricimonas paravirosa, a commensal gram-negative anaerobic bacterium identified by whole-genome sequencing in an elderly patient with acute terminal ileitis, who was successfully treated with ceftriaxone and metronidazole. We reviewed eleven previous cases of infection due to other Butyricimonas spp, which can cause a range of diseases but may be treated conservatively with a short antimicrobial course in the appropriate clinical setting. Additionally, while most Butyricimonas spp are susceptible to empiric anaerobic therapy, drug resistance has been reported in some cases.

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  • Immunocompromised patients, like those with Bruton's X-linked agammaglobulinemia, are at high risk for repeated Campylobacter infections, particularly multi-drug resistant strains.
  • In a reported case, a patient experienced multiple bloodstream infections due to Campylobacter jejuni, with the fifth recurrence showing carbapenem resistance linked to specific genetic mutations.
  • The infection was successfully treated with a combination of antibiotics, initially using cefepime and doxycycline, and later switching to moxifloxacin.
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  • A new method for evaluating student attention in class uses the head Euler angle, combining video sampling strategies with dynamic thresholds to measure attention through head movement.
  • The method calculates "head up rate" and "head front-facing rate" from video data, allowing for a derived concentration score by normalizing these measurements.
  • Accuracy tests show this approach achieves 89.8% accuracy against survey scores and 98.43% accuracy across different head pose estimation models, demonstrating its reliability and robustness in assessing classroom concentration.
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  • Extreme myopia (EM) is a serious cause of vision loss, defined as having a spherical equivalent of -10.00 diopters or worse, and current genetic knowledge about it is limited.
  • Researchers conducted whole-exome sequencing on 449 individuals with EM compared to 9,606 controls, finding an excess of rare protein-truncating variants linked to a specific cellular transport pathway.
  • Using advanced sequencing techniques, they identified specific fibroblasts (PI16+/SFRP4+) as crucial in understanding EM, and the study revealed that the gene KDELR3 plays a significant role in eye structure, influencing the development of elongated eyes in a zebrafish model.
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Background: Osteosarcoma (OS) is one of the most common primary malignant tumors of bone in children, which develops from osteoblasts and typically occurs during the rapid growth phase of the bone. Recently, Super-Enhancers(SEs)have been reported to play a crucial role in osteosarcoma growth and metastasis. Therefore, there is an urgent need to identify specific targeted inhibitors of SEs to assist clinical therapy.

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Background: Despite the use of targeted therapeutic approaches, T-cell acute lymphoblastic leukemia (T-ALL) is still associated with a high incidence of complications and a poor prognosis. Indisulam (also known as E7070), a newly identified molecular glue compound, has demonstrated increased therapeutic efficacy in several types of cancer through the rapid degradation of RBM39. This study aimed to evaluate the therapeutic potential of indisulam in T-ALL, elucidate its underlying mechanisms and explore the role of the RBM39 gene.

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Background: Necrotizing enterocolitis (NEC) is a severe neonatal intestinal disease, often occurring in preterm infants following the administration of hyperosmolar formula. It is one of the leading causes of neonatal mortality in the NICU, and currently, there are no clear standards for surgical intervention, which typically depends on the joint discretion of surgeons and neonatologists. In recent years, deep learning has been extensively applied in areas such as image segmentation, fracture and pneumonia classification, drug development, and pathological diagnosis.

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Background: Super-enhancers (SEs) typically govern the expression of critical oncogenes and play a fundamental role in the initiation and progression of cancer. Focusing on genes that are abnormally regulated by SE in cancer may be a new strategy for understanding pathogenesis. In the context of this investigation, we have identified a previously unreported SE-driven gene IRF2BP2 in neuroblastoma (NB).

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As the field of 2D materials rapidly evolves, substances such as graphene, metal dichalcogenides, MXenes, and MBenes have garnered extensive attention from scholars in the gas sensing domain due to their unique and superior properties. Based on first-principles calculations, this work explored the adsorption characteristics of both intrinsic and silver (Ag) doped tin disulfide (SnS) toward the decomposition components of the insulating medium CFN (namely, CF, CF, and COF), encompassing the adsorption energy, charge transfer, density of state (DOS), band structure, and adsorption stability. The results indicated that Ag-doped SnS exhibited an effective and stable adsorption for CF and COF, whereas its adsorption for CF was comparatively weaker.

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Glaesserella parasuis (G. parasuis) is the causative agent of porcine Glässer's disease, resulting in high mortality rates in pigs due to excessive inflammation-induced tissue damage. Previous studies investigating the protective effects of G.

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Background: Prior to the COVID-19 pandemic, Alberta was on track to meet national HCV elimination targets by 2030. However, it is unclear how the pandemic has affected progress. Here, we aim to assess the impact of first-wave COVID-19 restrictions on Alberta HCV testing trends.

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Super enhancers (SEs) are genomic regions comprising multiple closely spaced enhancers, typically occupied by a high density of cell-type-specific master transcription factors (TFs) and frequently enriched in key oncogenes in various tumors, including neuroblastoma (NB), one of the most prevalent malignant solid tumors in children originating from the neural crest. Cyclin-dependent kinase 5 regulatory subunit-associated protein 3 (CDK5RAP3) is a newly identified super-enhancer-driven gene regulated by master TFs in NB; however, its function in NB remains unclear. Through an integrated study of publicly available datasets and microarrays, we observed a significantly elevated CDK5RAP3 expression level in NB, associated with poor patient prognosis.

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Silicon-carbon composites have been recognized as some of the most promising anode candidates for advancing new-generation lithium-ion batteries (LIBs). The development of high-efficiency silicon/graphene anodes through a simple and cost-effective preparation route is significant. Herein, by using micron silicon as raw material, we designed a mesoporous composite of silicon/alumina/reduced graphene oxide (Si/AlO/RGO) a two-step ball milling combined annealing process.

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Background: Pheochromocytoma (PCC) is a rare neuroendocrine tumor. Angiogenesis is primary contributing factor for tumorigenesis. Cytochrome c oxidase 4I2 (COX4I2) has been confirmed to take part in the progression of cancer.

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Background: Acute myeloid leukemia (AML) is a malignancy of the hematopoietic system, and childhood AML accounts for about 20% of pediatric leukemia. ANP32B, an important nuclear protein associated with proliferation, has been found to regulate hematopoiesis and CML leukemogenesis by inhibiting p53 activity. However, recent study suggests that ANP32B exerts a suppressive effect on B-cell acute lymphoblastic leukemia (ALL) in mice by activating PU.

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  • * GNE-987 is a new drug developed using PROTAC technology, designed to target and degrade the BRD4 protein, which is crucial for T-ALL cell growth and survival.
  • * The study found that GNE-987 effectively inhibits T-ALL cell proliferation by targeting genes linked to super-enhancers, offering promising insights into its potential as a treatment for this aggressive leukemia.
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To evaluate functional outcomes of robot-assisted ureteroplasty with labial mucosa grafting for long proximal ureteral stenosis (LPUS) in children and adolescents. Included in this study were 15 patients who underwent robot-assisted ureteroplasty with labial mucosal grafting in our center between July 2017 and September 2021. The left affected stenotic ureter was repaired using labial mucosal grafting.

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To report our institutional experience and the medium-term outcomes of utilizing robotic-assisted laparoscopic surgery (RALS) in patients with Wilms' tumor (WT). The robotic surgical interventions include nephron-sparing surgery (RAL-NSS), radical nephrectomy (RAL-RN), and nephrectomy with inferior vena cava thrombectomy (RAL-N-IVCT). We retrospectively collected medical records of WT patients who underwent RALS in our center between August 2019 and February 2022.

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  • Triboelectric nanogenerators (TENGs) are promising for capturing environmental energy for applications like self-powered sensors, wearables, and corrosion protection, but their low output power limits their development.
  • The review emphasizes selecting and optimizing triboelectric materials to improve the surface charge density, which is crucial for TENG performance.
  • Various methods to enhance charge density are discussed, along with challenges and future research opportunities in the field.
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