Publications by authors named "Ran Zhou"

In and many other tree species, photoassimilate sucrose diffuses down a concentration gradient via symplastically connected mesophyll cells to minor vein phloem for long-distance transport. There is no evidence for apoplastic phloem-loading in . However, plasma membrane sucrose transporters (SUT1 and SUT3) orthologous to those associated with apoplastic phloem loading are expressed in vascular tissues of poplar.

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The segmentation and classification of carotid plaques in ultrasound images play important roles in the treatment of atherosclerosis and assessment for the risk of stroke. Although deep learning methods have been used for carotid plaque segmentation and classification, two-stage methods will increase the complexity of the overall analysis and the existing multi-task methods ignored the relationship between the segmentation and classification. These will lead to suboptimal performance as valuable information might not be fully leveraged across all tasks.

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The formation of the anther wall and the development of pollen processes, central to rice fertility and yield, are highly dependent on the synthesis and accumulation of lipid polymers. Although several regulatory factors related to lipid biosynthesis during pollen wall development have been identified, the molecular mechanisms controlling these processes remain poorly understood. In this study, a male-sterile rice mutant, , was identified, characterized by normal vegetative growth but complete male sterility due to delayed programmed cell death (PCD) in tapetal cells and defects in anther cuticle and pollen exine formation.

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Multi-axis contouring control is crucial for ultraprecision manufacturing industries, contributing to meeting the ever-increasingly stringent performance requirements. In this article, a novel contouring adaptive real-time iterative compensation (CARIC) method is proposed to achieve extreme multi-axis contouring accuracy, remarkable trajectory generalization, disturbance rejection, and parametric adaptation simultaneously. Specifically, control actions generated by CARIC consist of robust feedback, adaptive feedforward, and online trajectory compensation components.

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Objective: Early diagnosis of intensive care unit-acquired weakness (ICUAW) is crucial for improving the outcomes of critically ill patients. Hence, this study was designed to identify predisposing factors for ICUAW and establish a predictive model for the early diagnosis of ICUAW.

Methods: This prospective observational multicenter study included septic patients from the comprehensive ICUs of West China Hospital of Sichuan University and 10 other hospitals between September and November 2023.

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Total proctocolectomy with ileal pouch anal anastomosis is the standard of care for patients with severe ulcerative colitis. We generated a cell-type-resolved transcriptional and epigenetic atlas of ileal pouches using scRNA-seq and scATAC-seq data from paired biopsy samples of the ileal pouch and the ileal segment above the pouch (pre-pouch) from patients (male=4, female=2), and paired biopsies of the terminal ileum and ascending colon from healthy individuals (male=3, female=3) serving as reference. Our study finds an additional population of absorptive and secretory epithelial cells within the pouch but not the pre-pouch.

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Culm strength is crucial for rice growth, nutrition transportation, and structural resilience, which are essential for lodging resistance and stable production. In this study, we identified a rice thin culm mutant tc4, characterized by thinner culms and thicker cavity walls, resulting in weakened culm mechanical strength. Using map-based cloning, the candidate gene was isolated, and complementation and CRISPR/Cas9 experiments confirmed that a single nucleotide substitution in TC4 is responsible for the thin and brittle culm phenotype.

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Scientific evaluation of the effectiveness of ecological restoration could provide support for sustainable management and protection of wetlands. However, due to the multiple and difficult to quantify factors affecting wetlands, commonly used spatiotemporal evaluation methods were difficult to scientifically reflect the actual effectiveness of ecological restoration. This paper took Tianjin Qilihai Wetland, a representative wetland in northern China, as the research object.

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Objectives: The purpose of this study was to determine whether our new thinking guidance named OPACCUS (oxygen metabolism, perfusion, arterial tension, cardiac output, systemic congestion, unregulated host response and search for inciting illness event) with 7 questions you need to ask before shock therapy and evidences provided by critical ultrasound considering hemodynamics, the unregulated host response and inciting illness event would improve mortality in shock patients.

Design: A multicenter, prospective, observational cohort study.

Setting: Intensive care units of 20 hospitals in Southwest China.

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Crohn's disease (CD) is a complex inflammatory bowel disease resulting from an interplay of genetic, microbial, and environmental factors. Cell-type-specific contributions to CD etiology and genetic risk are incompletely understood. Here we built a comprehensive atlas of cell-type- resolved chromatin accessibility comprising 557,310 candidate cis-regulatory elements (cCREs) in terminal ileum and ascending colon from patients with active and inactive CD and healthy controls.

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Objective: This study aimed to analyse the causes of foetal mild-to-moderate isolated ventriculomegaly (IVM) and to evaluate the prognosis of neurological development in surviving children in different subgroups.

Methods: We retrospectively studied mild-to-moderate IVM diagnosed by prenatal ultrasound scans in different subgroups according to the laterality of IVM, the degree of IVM and foetal sex independently. The results of foetal chromosomal microarray analysis, virological tests of umbilical cord blood or amniotic fluid, foetal magnetic resonance imaging and ultrasound were collected.

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Over the past decade, high-throughput sequencing and high-resolution single-cell transcriptome sequencing technologies have undergone rapid development, leading to significant breakthroughs. Traditional molecular biology methods are limited in their ability to unravel cellular-level heterogeneity within woody plant tissues. Consequently, techniques such as single-cell transcriptomics, single-cell epigenetics, and spatial transcriptomics are rapidly gaining popularity in the study of woody plants.

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alginate is a good candidate for encapsulating bioactive compounds because the Na on its carboxyl groups can take part in an ion exchange process with Ca to generate a calcium alginate shell. Electrospraying technology was used to prepare cinnamaldehyde (CA)-loaded alginate microcapsules. The generation of microcapsules with a minimal diameter could improve the mass transfer of encapsulated materials.

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Early detection and intervention of cancer or precancerous lesions hold great promise to improve patient survival. However, the processes of cancer initiation and the normal-precancer-cancer progression within a non-cancerous tissue context remain poorly understood. This is, in part, due to the scarcity of early-stage clinical samples or suitable models to study early cancer.

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Article Synopsis
  • The study investigates how therapeutic hypothermia (TH) affects heart damage caused by ischemia-reperfusion (I/R) injury using rat models and cardiac cells.
  • Results show that TH decreases the size of heart damage, lowers serum levels of injury markers, and reduces inflammation and cell death associated with I/R injury.
  • TH's protective effects may be linked to the DKK3/Wnt/β-catenin signaling pathway, suggesting potential mechanisms for treating heart conditions.
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Article Synopsis
  • * The genome is approximately 1.43 Gb in size, mostly organized into 9 pseudochromosomes, with a completeness rate of 97.27% and a high quality value indicating a well-assembled genome.
  • * The genome contains nearly 30,000 protein-coding genes, including those related to flavonoid production and transcription factors, paving the way for advanced studies in the genetics of Leguminosae species.
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Article Synopsis
  • Manipulating gene expression is key for understanding how genes work, and RNA-seq is a useful tool for exploring these mechanisms, but inconsistent metadata hinders data reuse.
  • To solve this, PerturbAtlas was created as a resource that re-analyzes RNA-seq data to deliver detailed statistics on gene expression and transcript changes after genetic modifications.
  • The platform compiles data from over 122,000 RNA-seq libraries across 13 species and is available online for free, enabling users to easily investigate gene and isoform trends based on various search criteria.
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Endometrial receptivity is the ability of the endometrium to accept embryos. Thus, endometrial receptivity dysfunction is an important factor leading to embryo implantation failure. A good endometrial receptivity provides a suitable environment for embryo implantation, improving the embryo implantation rate.

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Recent studies have suggested that there may be a relationship between hiatal hernia (HH) and atrial fibrillation (AF), but the specific mechanism is unclear. The aim of this study was to explore the clinical characteristics associated with HH and AF and to identify the potential relationship between the 2 diseases. The study comprised 180 patients with HH, of which 54 had AF.

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Article Synopsis
  • The flowering period of rice is crucial for its adaptability and yield, and can be optimized through genome editing techniques like CRISPR/Cas9.
  • A new multiplex genome-editing vector targeting five flowering-related genes was developed and introduced into the Jiahe212 rice variety, resulting in mutant plants with varied flowering times.
  • Three specific mutant lines flowered earlier without significantly affecting yield, providing valuable resources for future rice breeding efforts aimed at improving adaptability and creating hybrids.
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Background: Sepsis triggers a strong inflammatory response, often leading to organ failure and high mortality. The role of serum albumin levels in sepsis is critical but not fully understood, particularly regarding the significance of albumin level changes over time. This study utilized Group-based Trajectory Modeling (GBTM) to investigate the patterns of serum albumin changes and their impact on sepsis outcomes.

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The aim of this research was to investigate the effects of supercritical carbon dioxide (SC-CO) treatment on protein structure in Mongolian cheese. The peptides during the digestive process of the SC-CO treated cheese were also studied. SC-CO technology was utilized to treat Mongolian cheese at three temperatures (45, 55 and 65 °C) and three pressures (7.

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Chitinase plays a vital role in the virulence of entomopathogenic fungi (EPF) when it infects host insects. We used gene recombination technology to express chitinase of three strains of Lecanicillium lecanii: Vl6063, V3450, and Vp28. The ORF of ChitVl6063, ChitV3450 and ChitVp28 were inserted into the fungal expression vector pBARGPE-1, which contained strong promoter and terminator, respectively, to construct a chitinase overpressing plasmid, then transformed the wild-type strain with blastospore transformation method.

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Three key factors determine yield in rice (Oryza sativa): panicle number, grain number, and grain weight. Panicle number is strongly associated with tiller number. Although many genes regulating tillering have been identified, whether Dof proteins are involved in controlling plant architecture remains unknown.

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