Bioinformatic analysis of molecular expression patterns during the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD).

The global incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) continues to rise, primarily driven by the escalating obesity epidemic worldwide. MASLD, a spectrum of liver disorders, can progress to more severe conditions, metabolic dysfunction-associated steatohepatitis (MASH), ultimately culminating in hepatocellular carcinoma (HCC). Given the complex nature of MASLD, there is an urgent need to develop robust risk prediction models and design specialized cancer screening initiatives tailored specifically for individuals with MASLD.

MAGI3 enhances sensitivity to sunitinib in renal cell carcinoma by suppressing the MAS/ERK axis and serves as a prognostic marker.

Clear cell renal cell carcinoma (ccRCC) exhibits considerable heterogeneity, with approximately 25% of localized cases susceptible to relapse, highlighting the challenge of the absence of reliable predictive biomarkers for personalized treatment. Meanwhile, metastatic renal cell carcinoma is characterized by unfavorable survival rates, and although Sunitinib offers partial benefits, the clinical advantages are often constrained by drug resistance and adverse side effects. Here, MAGI3 was associate with ccRCC progression, as identified through comprehensive bioinformatics analysis of clinical datasets.

Risk factors for loss to follow-up in patients with gout: A Korean prospective cohort study.

Objectives: Gout, a common form of inflammatory arthritis, is often managed with urate-lowering therapy, but many patients only adhere to treatment during gout attacks, resulting in poor follow-up and suboptimal management. This study aimed to identify characteristics associated with loss to follow-up (LTFU) and develop strategies for better patient management.

Methods: Data were analyzed from the Urate Lowering TheRApy in gout (ULTRA) registry, a prospective cohort of Korean gout patients recruited since September 2021.

Telomere Length and Oxidative Damage in Children and Adolescents with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.

Background: Autism spectrum disorder (ASD) has been reported to confer an increased risk of natural premature death. Telomere erosion caused by oxidative stress is a common consequence in age-related diseases. However, whether telomere length (TL) and oxidative indicators are significantly changed in ASD patients compared with controls remains controversial.

Dinuclear Dicationic Iridium Complexes for Highly Synergistic Photodynamic and Photothermal Therapy to Chemoresistant Cancer.

A series of dinuclear Ir(III) complexes have been constructed for enhanced photodynamic and photothermal therapy (PDT and PTT) for cisplatin-resistant non-small-cell lung cancer. They enter cells via caveolar endocytosis, target mitochondria but not nuclear, generate both singlet oxygen and superoxide anion, and release heat when exposed to infrared (IR) irradiation, thus inducing reactive oxygen species (ROS)-associated cell disruption and thermal ablation. The IR-generated ROS can further activate caspases, triggering apoptosis.

A meta-analysis comparing open and minimally invasive cervical tumor surgery wound infection and postoperative complications.

To evaluate the impact of open surgical care (OSC) compared to minimally invasive surgery (MIS) on the occurrence of wound infection (WI) and overall postoperative aggregate complications (POACs) in female cervical cancer (CC) patients, we conducted this meta-analysis study. A thorough examination of the literature up to March 2024 was conducted, and 1849 related studies were examined. The 44 studies that were selected included 11,631 females who had CC.

Structural basis for Retriever-SNX17 assembly and endosomal sorting.

During endosomal recycling, Sorting Nexin 17 (SNX17) facilitates the transport of numerous membrane cargo proteins by tethering them to the Retriever complex. Despite its importance, the mechanisms underlying this interaction have remained elusive. Here, we provide biochemical, structural, cellular, and proteomic analyses of the SNX17-Retriever interaction.

Screening, Gene Cloning and Expression of Cellulase-Producing Strain Bacillus subtilis Xh-16.

Cellulase is a complex enzyme system composed of multiple hydrolytic enzymes. It can degrade cellulose into glucose and improve the utilization efficiency of cellulose resources. Cellulase produced by microorganisms is the main method used in industry, offering the advantages of convenience and being environmentally friendly.

Unveiling the Clinical Path of Microinvasive Breast Cancer: A Comparative Study With Tis-T1 Breast Cancer.

Purpose: The prognosis of microinvasive breast cancer (MIBC) is controversial, with a high reported rate of local recurrence (LR). This study aimed to evaluate the characteristics, treatments, and prognosis of patients with MIBC compared to those with carcinoma in situ (CIS) or early invasive cancer.

Methods: Patients who diagnosed with CIS or stage I breast cancer were retrospectively enrolled.

Prediction of lymphovascular invasion of gastric cancer based on contrast-enhanced computed tomography radiomics.

Background: Lymphovascular invasion (LVI) is a significant risk factor for lymph node metastasis in gastric cancer (GC) and is closely related to the prognosis and recurrence of GC. This study aimed to establish clinical models, radiomics models and combination models for the diagnosis of GC vascular invasion.

Methods: This study enrolled 146 patients with GC proved by pathology and who underwent radical resection of GC.

Camouflaging endovascular stents with an endothelial coat using CD31 domain 1 and 2 mimetic peptides.

Objective: Implantation of an endovascular device disrupts the homeostatic CD31:CD31 interactions among quiescent endothelial cells (ECs), platelets, and circulating leukocytes. The aim of this study was to design an endothelial-mimetic coating of nitinol and cobalt-chromium (CoCr) surfaces and stents using synthetic CD31 peptides, to promote device endothelialization and pacific integration within the arterial wall.

Methods: Peptides mimicking the domains 1 (D1) and 2 (D2) of CD31 were synthetized and immobilized onto experimental nitinol and CoCr surfaces using a three-step, dip-coating, mussel-inspired protocol using copper-free click chemistry.

Asymmetric 1,4-Reduction of Pyrano[2,3-]indoles with Hantzsch Ester by Chiral Phosphoric Acid.

A highly regioselective and enantioselective transfer hydrogenation of pyrano[2,3-]indoles with Hantzsch ester has been successfully realized using spiro-chiral phosphoric acid, affording a series of optically active 1,4-reductive adducts, 4,9-dihydropyrano[2,3-]indoles, in 34-99% yields with 61-99% .

Learning Common Semantics via Optimal Transport for Contrastive Multi-View Clustering.

Multi-view clustering aims to learn discriminative representations from multi-view data. Although existing methods show impressive performance by leveraging contrastive learning to tackle the representation gap between every two views, they share the common limitation of not performing semantic alignment from a global perspective, resulting in the undermining of semantic patterns in multi-view data. This paper presents CSOT, namely Common Semantics via Optimal Transport, to boost contrastive multi-view clustering via semantic learning in a common space that integrates all views.

Switchable Chemoselectivity in [3 + 3] Annulation of β,γ-Unsaturated α-Ketoesters and 1Pyrazol-5-amines by Cooperative Acid Catalysis with Ni and In.

The exchange of the metal ion from Ni(II) to In(I) leads to a switch in the chemoselectivity of the [3 + 3] annulation of β,γ-unsaturated α-ketoesters and 1pyrazol-5-amines in the presence of phosphoric acid , affording functionalized 1pyrazolo[3,4-]pyridines in up to 97% yields and highly enantioselective 4,5-dihydro-1-pyrazolo[3,4-]pyridines in up to 92% yield and 99% ee.

Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice.

Despite the availability of life-extending treatments for B cell leukemias and lymphomas, many of these cancers remain incurable. Thus, the development of new molecular targets and therapeutics is needed to expand treatment options. To identify new molecular targets, we used a forward genetic screen in mice to identify genes required for development or survival of lymphocytes.

From Intercalation to External Binding: Ru(II) Complexes with a Spiro Ligand for TAR RNA Selective Binding and HIV-1 Reverse Transcriptase Inhibition.

As a typical RNA virus, the genetic information on HIV-1 is entirely stored in RNA. The reverse transcription activity of HIV-1 reverse transcriptase (RT) plays a crucial role in the replication and transmission of the virus. Non-nucleoside RT inhibitors (NNRTIs) block the function of RT by binding to the RNA binding site on RT, with very few targeting viral RNA.

PDZK1 confers sensitivity to sunitinib in clear cell renal cell carcinoma by suppressing the PDGFR-β pathway.

Background: Sunitinib has emerged as the primary treatment for advanced or metastatic clear cell renal cell carcinoma (ccRCC) due to its significant improvement in patients' average survival time. However, drug resistance and adverse effects of sunitinib pose challenges to its clinical benefits.

Methods: The differentially expressed genes (DEGs) associated with sunitinib sensitivity and resistance in ccRCC were investigated.

IGCN: A Provably Informative GCN Embedding for Semi-Supervised Learning With Extremely Limited Labels.

Graph Neural Networks (GNNs) have gained much more attention in the representation learning for the graph-structured data. However, the labels are always limited in the graph, which easily leads to the overfitting problem and causes the poor performance. To solve this problem, we propose a new framework called IGCN, short for Informative Graph Convolutional Network, where the objective of IGCN is designed to obtain the informative embeddings via discarding the task-irrelevant information of the graph data based on the mutual information.

DeTAL: Open-Vocabulary Temporal Action Localization With Decoupled Networks.

Pre-trained visual-language (ViL) models have demonstrated good zero-shot capability in video understanding tasks, where they were usually adapted through fine-tuning or temporal modeling. However, in the task of open-vocabulary temporal action localization (OV-TAL), such adaption reduces the robustness of ViL models against different data distributions, leading to a misalignment between visual representations and text descriptions of unseen action categories. As a result, existing methods often strike a trade-off between action detection and classification.

Switchable Enantioselectivity in Conjugate Alkyne Addition of β,γ-Unsaturated α-Keto Esters by Asymmetric Binary Acid Catalysis.

Switchable enantioselectivity was uncovered in the enantioselective catalytic conjugate addition of β,γ-unsaturated α-keto esters with terminal alkynes to the chiral Lewis acid complex of In(BF) and chiral phosphoric acid.

A machine learning based method for constructing group profiles of university students.

This study facilitates university student profiling by constructing a prediction model to forecast the classification of future students participating in a survey, thereby enhancing the utility and effectiveness of the questionnaire approach. In the context of the ongoing digital transformation of campuses, higher education institutions are increasingly prioritizing student educational development. This shift aligns with the maturation of big data technology, prompting scholars to focus on profiling university student education.

Structural basis for Retriever-SNX17 assembly and endosomal sorting.

During endosomal recycling, Sorting Nexin 17 (SNX17) facilitates the transport of numerous membrane cargo proteins by tethering them to the Retriever complex. Despite its importance, the mechanisms underlying this interaction have remained elusive. Here, we report the structure of the Retriever-SNX17 complex determined using cryogenic electron microscopy (cryo-EM).

A green aqueous binder to enhance the electrochemical performance of Li-rich disordered rock salt cathode material.

Li-rich disordered rock-salt oxides (DRX) are considered an attractive cathode material in the future battery field due to their excellent energy density and specific capacity. Nevertheless, anionic redox provides high capacity while causing O over-oxidation to O, resulting in voltage hysteresis and capacity decay. Herein, the crystal structure of LiMnTiOF (LMTOF) cathode is stabilized by using sodium carboxymethylcellulose (CMC) binders replacing traditional polyvinylidene difluoride (PVDF) binders.