Aberrant upregulation of PDK1 in ovarian cancer cells impairs CD8 T cell function and survival through elevation of PD-L1.

Blockade of the programmed cell death 1(PD-1)/PD-1 ligand-1(PD-L1) pathway has been exploited therapeutically in many cancer types. Upregulation of PD-L1 in tumor cells contributes to malignancy through suppression of the T cell-mediated antitumor response. Pyruvate dehydrogenase kinase 1 (PDK1), a glycolytic gate-keeping enzyme, is also known to promote tumor development.

[Carbon storage and sequestration potential of five typical plantation ecosystems in Gansu Province, China].

Based on the data of the field investigation and laboratory and the database of the 8 national forestry inventory, ecosystem carbon density, storage amount, and sequestration potential of tree layer were estimated for five typical plantation ecosystems (Robinia pseudoacacia, Populus spp., Pinus tabuliformis Pinus armandii, which were grouped as one kind of ecosystems, Larix principis-rupprechtii, and Picea asperata) in Gansu Province. The results showed that the average carbon density and total carbon storage of the five typical plantation ecosystems were 139.