Pharmacogenomics Guided Prescription Changes Improved Medication Effectiveness in Patients With Mental Health-Related Disability: A Retrospective Cohort Analyses.

Mental health problems are the leading cause of disability in Canadian workers. Medication ineffectiveness is hypothesized to increase the time to return-to-work in these workers. We assessed whether prescription changes based on pharmacogenomics profiling ( Report) improved medication effectiveness in patients on mental health-related disability.

Polygenic risk scores predict diabetes complications and their response to intensive blood pressure and glucose control.

Aims/hypothesis: Type 2 diabetes increases the risk of cardiovascular and renal complications, but early risk prediction could lead to timely intervention and better outcomes. Genetic information can be used to enable early detection of risk.

Methods: We developed a multi-polygenic risk score (multiPRS) that combines ten weighted PRSs (10 wPRS) composed of 598 SNPs associated with main risk factors and outcomes of type 2 diabetes, derived from summary statistics data of genome-wide association studies.

Correlation of fall efficacy scale and Hendrich fall risk model in elder population of Rawalpindi-Islamabad.

Objective: To determine the correlation of fall efficacy scale and Hendrich fall risk model in elderly population.

Methods: The correlational study was conducted from February to July 2018 in the twin cities of Islamabad and Rawalpindi, Pakistan, and comprised subjects of either gender aged >65 years from Railway General Hospital, Rawalpindi Eye Donors Organisation Eye Hospital, Water and Power Development Authority General Hospital, as well as Baghban and Mukhtar Ghulam Qadir(MGQ)old people's homes. A pre-designed semi structured questionnaire consisting of Fall Efficacy Scale-International, Hendrich fall risk model along with the necessary demographic information was used for data collection.

Impact of early use of long-acting injectable antipsychotics on psychotic relapses and hospitalizations in first-episode psychosis.

Early relapse is frequent in the first-episode psychosis (FEP), often because of poor adherence to medication. Previous studies have shown positive impacts of long-acting injectable antipsychotics (LAI-AP) on relapse rates, while others have discerned no differences. This study describes the impact of early LAI-AP utilization on relapse and rehospitalization rates in FEP.

Long-acting antipsychotic medication as first-line treatment of first-episode psychosis with comorbid substance use disorder.

Aim: Substance use disorder (SUD) is highly prevalent among patients with first-episode psychosis (FEP) and associated with poor adherence and worst treatment outcomes. Although relapses are frequent in FEP, current literature on long-acting injectable antipsychotics (LAI-AP) use in FEP is scarce and studies often exclude patients with SUD.

Objectives: To determine the impact of LAI-AP as first-line treatment on psychotic relapses or rehospitalizations in FEP patients with comorbid SUD (FEP-SUD).

Combined Effect of Aerobic and Resistance Interval Training on Ejection Fraction in Myocardial Infarction.

This study was conducted to determine whether combination of aerobic and resistance interval training had superior effects than aerobic interval training alone on ejection fraction, cholesterol, and triglycerides in myocardial infarction patients, at Pakistan Railway General Hospital Rawalpindi from July to December 2016. Patients were randomly allocated in interventional (n=13) and control group (n=13) using toss and trial method. Aerobic interval training at 65%-85% of target heart rate was performed in three intervals in both groups; whereas, resistance training at 30-50% of one repetition maximum was added in experimental group.

Comparison of hypertabastic survival model with other unimodal hazard rate functions using a goodness-of-fit test.

We studied the problem of testing a hypothesized distribution in survival regression models when the data is right censored and survival times are influenced by covariates. A modified chi-squared type test, known as Nikulin-Rao-Robson statistic, is applied for the comparison of accelerated failure time models. This statistic is used to test the goodness-of-fit for hypertabastic survival model and four other unimodal hazard rate functions.